16026-77-0

Usage

Uses

Used in Chemical Synthesis:
3-Amino-4-chlorophenol is used as a chemical intermediate for the synthesis of various compounds, including hydroxymethyl rhodamines (HMRs). These HMRs are important due to their potential applications in different fields, such as biochemistry and medical imaging, where they can be used as fluorescent markers or indicators.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-Amino-4-chlorophenol may be utilized as a building block for the development of new drugs. Its unique structure allows for the creation of novel molecules with potential therapeutic properties, contributing to the advancement of medicinal chemistry.
Used in Dye Manufacturing:
3-Amino-4-chlorophenol can also be employed in the manufacturing of dyes, particularly those that require specific color properties. Its chemical structure makes it a suitable candidate for the production of dyes with desired characteristics, such as colorfastness and stability.
Used in Research and Development:
Due to its unique chemical properties, 3-Amino-4-chlorophenol may be used in research and development for exploring new reactions and understanding the behavior of similar compounds. This can lead to the discovery of new applications and advancements in various scientific fields.

InChI:InChI=1/C6H6ClNO/c7-5-2-1-4(9)3-6(5)8/h1-3,9H,8H2

Upstream product

• 7647-01-0 hydrogenchloride 
• 610-78-6 3-nitro-4-chlorophenol 
• 7646-78-8 tin(IV) chloride 

Downstream Products

• 1020172-85-3 2-chloro-5-(5-fluoropyridin-3-yloxy)benzenamine 
• 438249-25-3 4-(2-Chloro-5-hydroxyanilino)-2-(2-pyridinyl)-6-trifluoromethylpyrimidine 
• 438248-41-0 4-(2-Chloro-5-hydroxyanilino)-2-(3-pyridinyl)-6-(trifluoromethyl)pyrimidine 
• 438249-30-0 4-(2-Chloro-5-hydroxyanilino)-2-(2-pyrazinyl)-6-trifluoromethylpyrimidine 
• 932707-19-2 8-chloro-3-(4-chlorophenylsulfanyl)-2,4-dimethylquinolin-5-ol 
• 932706-95-1 8-chloro-3-(4-chlorobenzyl)-5-hydroxy-2-methyl-1H-quinolin-4-one 
• 932707-94-3 N-(2-chloro-5-hydroxyphenyl)-2-(4-methanesulfonylbenzyl)-3-oxo-butyramide 
• 932707-00-1 8-chloro-3-(4-chlorobenzyl)-2,4-dimethylquinolin-5-ol 
• 932707-16-9 8-chloro-3-(4-chlorophenoxy)-2,4-dimethylquinolin-5-ol 
• 879503-83-0 C₁₁H₈ClN₃O₂ 
• 879503-84-1 C₁₁H₇Cl₂N₃O₂ 
• 879503-85-2 C₁₅H₁₆ClN₃O₂ 
• 879503-86-3 C₁₅H₁₅Cl₂N₃O₂ 
• 1092394-35-8 tert-butyl {2-chloro-5-[(6-nitropyridin-3-yl)oxy]phenyl}carbamate 

Relevant academic research and scientific papers

Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment

The proto-oncogene c-Src is a non-receptor tyrosine kinase which is involved in the regulation of many cellular processes, such as differentiation, adhesion and survival. c-Src hyperactivation has been detected in many tumors, including neuroblastoma (NB), one of the major causes of death from neoplasia in infancy. We already reported a large family of pyrazolo[3,4-d]pyrimidines active as c-Src inhibitors. Interestingly, some of these derivatives resulted also active on SH-SY5Y NB cell line. Herein, starting from our previous Free Energy Perturbation/Monte Carlo calculations, we report an optimization study which led to the identification of a new series of derivatives endowed with nanomolar Ki values against c-Src, interesting antiproliferative activity on SH-SY5Y cells and a suitable ADME profile.

A capping agent dissolution method for the synthesis of metal nanosponges and their catalytic activity towards nitroarene reduction under mild conditions

We report a general strategy for the synthesis of metal nanosponges (M = Ag, Au, Pt, Pd, and Cu) using a capping agent dissolution method where addition of water to the M@BNHx nanocomposite affords the metal nanosponges. The B-H bond of the BNHx polymer gets hydrolysed upon addition of water and produces hydrogen gas bubbles which act as dynamic templates leading to the formation of nanosponges. The rate of B-H bond hydrolysis has a direct impact on the final nanostructure of the materials. The metal nanosponges were characterized using powder XRD, electron microscopy, XPS, and BET surface area analyzer techniques. The porous structure of these nanosponges offers a large number of accessible surface sites for catalytic reactions. The catalytic activity of these metal nanosponges has been demonstrated for the reduction of 4-nitrophenol where palladium exhibits the highest catalytic activity (k = 0.314 min?1). The catalytic activity of palladium nanosponge was verified for the tandem dehydrogenation of ammonia borane and the hydrogenation of nitroarenes to arylamines in methanol at room temperature. The reduction of various substituted nitroarenes was proven to be functional group tolerant except for a few halogenated nitroarenes (X = Br and I) and >99% conversion was noted within 30-60 min with high turnover frequencies (TOF) at low catalyst loading (0.1 mol%). The catalyst could be easily separated out from the reaction mixture via centrifugation and was recyclable over several cycles, retaining its porous structure.

Zwitterionic Surfactant stabilized palladium nanoparticles as catalysts in aromatic nitro compound reductions

Palladium nanoparticles (NPs) stabilized by ImS3-14, a zwitterionic surfactant structurally related to ionic liquids, are revealed here to be good catalysts for the reduction of a large number of substituted aromatic nitro compounds. Our mass spectrometry results are consistent with the formation of amino products in a direct route, where the aromatic nitro compounds are initially reduced to nitroso compounds, which are then reduced to the hydroxylamine derivatives and finally to the anilines. Activation parameters showed that for most Pd catalysts reported in the literature, the mechanism seems to be similar, with lower enthalpy of activation (ΔH?) being compensated by more negative entropy of activation (ΔS?). As a result, the reaction is thermally compensated and the rate constants for most reactions rather similar. Furthermore, Pd NPs stabilized by ImS3-14 showed efficient catalytic activities for the reduction of aromatic nitro compounds, with high conversion and good selectivity even using very low loadings of metal.

TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS

The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): wherein W, X, Y, Z, R1, R2, R5, and R8 are as described herein.

Hydrazine-mediated reduction of nitro and azide functionalities catalyzed by highly active and reusable magnetic iron oxide nanocrystals

Iron oxide (Fe3O4) nanocrystals generated in situ from an inexpensive and readily available iron source catalyze the reduction of nitroarenes to anilines with unparalleled efficiency. The procedure is chemoselective, avoids the use of precious metals, and can be applied under mild reflux conditions (65 or 80 C) or using sealed vessel microwave heating in an elevated temperature regime (150 C). Utilizing microwave conditions, a variety of functionalized anilines have been prepared in nearly quantitative yields within 2-8 min at 150 C, in a procedure also successfully applied to the reduction of aliphatic nitro compounds and azides. The iron oxide nanoparticles are generated in a colloidal form, resulting in homogeneous solutions suitable for continuous flow processing. Selected examples of anilines of industrial importance have been prepared in a continuous regime using this protocol.

Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators or caspases and inducers of apoptosis and the use thereof

The present invention is directed to substituted 2-aryl-4-arylaminopyrimidine and analogs thereof, represented by the general Formula I: wherein A, Ar1, Ar2, R1 and R3 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. The compounds of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.