(R)-3-bromo-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo-[1,2-b]pyridazine

Base Information

Chemical Name:(R)-3-bromo-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo-[1,2-b]pyridazine
CAS No.:1365212-61-8
Molecular Formula:C₁₆H₁₄BrFN₄
Molecular Weight:361.216
Hs Code.:

Synonyms:(R)-3-bromo-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo-[1,2-b]pyridazine

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Chemical Property of (R)-3-bromo-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo-[1,2-b]pyridazine

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Technology Process of (R)-3-bromo-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo-[1,2-b]pyridazine

There total 2 articles about (R)-3-bromo-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo-[1,2-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1364890-61-8
(2R)-2-(3-fluorophenyl)pyrrolidine hydrochloride

: 13526-66-4
3-bromo-6-chloro-imidazo[1,2-b]pyridazine

: 1365212-61-8
(R)-3-bromo-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo-[1,2-b]pyridazine

Guidance literature:: (2R)-2-(3-fluorophenyl)pyrrolidine hydrochloride; With sodium hydroxide; In water; for 0.333333h;

3-bromo-6-chloro-imidazo[1,2-b]pyridazine; With potassium fluoride; In dimethyl sulfoxide; at 100 ℃; for 72h;

Reference yield:

: 6775-78-6
6-chloroimidazo[1,2-b]pyridazine

: 1365212-61-8
(R)-3-bromo-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo-[1,2-b]pyridazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 0 °C

2.1: sodium hydroxide / water / 0.33 h

2.2: 72 h / 100 °C

With N-Bromosuccinimide; sodium hydroxide; In water; N,N-dimethyl-formamide;

Reference yield: 98.0%

: 212127-83-8
tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,5-dihydropyrrole-1-carboxylate

: 1365212-61-8
(R)-3-bromo-6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo-[1,2-b]pyridazine

: tert-butyl (R)-3 -(6-(2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)-2,5-dihydro-1H-pyrrole-1-carboxylate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 100 ℃; for 4h; Inert atmosphere;