6-Chloroimidazo[2,1-f]pyridazine

Base Information

• Chemical Name: 6-Chloroimidazo[2,1-f]pyridazine
• CAS No.: 6775-78-6
• Molecular Formula: C6H4ClN3
• Molecular Weight: 153.571
• Hs Code.: 2933990090
• Mol file: 6775-78-6.mol

Synonyms:6-Chloroimidazo[1,2-b]pyridazine;

Chemical Property of 6-Chloroimidazo[2,1-f]pyridazine

Chemical Property:

• Melting Point: 114.0 to 118.0 °C
• Refractive Index: 1.713
• PKA: 3.68±0.30(Predicted)
• PSA: 30.19000
• Density: 1.514 g/cm³
• LogP: 1.38270
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

6-Chloroimidazo[1,2-b]pyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-chloroimidazo[1,2-b]pyridazine (cas# 6775-78-6) is a useful research chemical.

Technology Process of 6-Chloroimidazo[2,1-f]pyridazine

There total 9 articles about 6-Chloroimidazo[2,1-f]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-chloroethanal (107-20-0) + 6-chloro-pyridazin-3-ylamine (5469-69-2) → 6-chloroimidazo[1,2-b]pyridazine (6775-78-6)

Guidance literature:

With zinc(II) oxide; In water; butan-1-ol; at 100 ℃; for 3h;

DOI:10.1002/jccs.201800332

Reference yield: 90.77%

6-chloro-pyridazin-3-ylamine (5469-69-2) + Bromoacetaldehyde diethyl acetal (2032-35-1) → 6-chloroimidazo[1,2-b]pyridazine (6775-78-6)

Guidance literature:

With hydrogen bromide; In ethanol; water; at 100 ℃; for 8h;

DOI:10.1016/j.bmc.2021.116186

Reference yield: 87.0%

6-chloro-pyridazin-3-ylamine (5469-69-2) + chloroacetaldehyde dimethyl acetal (97-97-2) → 6-chloroimidazo[1,2-b]pyridazine (6775-78-6)

Guidance literature:

With hydrogenchloride; sodium acetate; In ethanol; water; at 80 - 85 ℃; for 16h;

DOI:10.1016/j.bmcl.2017.11.026

upstream raw materials:

3-(2-Hydroxy-ethylamino)-6-chlor-pyridazin

2-chloroethanal

6-chloro-pyridazin-3-ylamine

bromoacetaldehyde

Downstream raw materials:

6-Chloro-9-methyl-9-phenyl-9H-imidazo<1,2-b>pyrazolo<4,3-d>pyridazine

6-Chloro-9-methyl-9-phenyl-7,8-dihydro-9H-imidazo<1,2-b>pyrazolo<4,3-d>pyridazine

3-bromo-6-chloro-imidazo[1,2-b]pyridazine

6-chloro-3-nitroimidazo<1,2-b>pyridazine