3,5-bis[(E)-(2-bromophenyl)methylidene]-1-[(R)-1-phenylethyl]tetrahydro-4(1H)-pyridinone

Base Information

• Chemical Name: 3,5-bis[(E)-(2-bromophenyl)methylidene]-1-[(R)-1-phenylethyl]tetrahydro-4(1H)-pyridinone
• CAS No.: 1245653-62-6
• Molecular Formula: C₂₇H₂₃Br₂NO
• Molecular Weight: 537.294

Synonyms:3,5-bis[(E)-(2-bromophenyl)methylidene]-1-[(R)-1-phenylethyl]tetrahydro-4(1H)-pyridinone

Chemical Property of 3,5-bis[(E)-(2-bromophenyl)methylidene]-1-[(R)-1-phenylethyl]tetrahydro-4(1H)-pyridinone

Chemical Property:

Purity/Quality:

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Technology Process of 3,5-bis[(E)-(2-bromophenyl)methylidene]-1-[(R)-1-phenylethyl]tetrahydro-4(1H)-pyridinone

There total 1 articles about 3,5-bis[(E)-(2-bromophenyl)methylidene]-1-[(R)-1-phenylethyl]tetrahydro-4(1H)-pyridinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(R)-1-(1-phenylethyl)tetrahydro-4(1H)-pyridinone (120343-66-0) + ortho-bromobenzaldehyde (6630-33-7) → 3,5-bis[(E)-(2-bromophenyl)methylidene]-1-[(R)-1-phenylethyl]tetrahydro-4(1H)-pyridinone (1245653-62-6)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃; for 0.166667h;

DOI:10.1016/j.tetasy.2010.03.054

Reference yield: 25.0%

3,5-bis[(E)-(2-bromophenyl)methylidene]-1-[(R)-1-phenylethyl]tetrahydro-4(1H)-pyridinone (1245653-62-6) + benzohydroximoyl chloride (698-16-8) → (5R,6R,10S)-10-(2-bromophenyl)-14-[(E)-1-(2-bromophenyl)methylidene]-3,9-diphenyl-12-(1-phenylethyl)-1,4,7-trioxa-2,8,12-triazadispiro[4.0.4.4]tetradeca-2,8-diene (1245653-89-7) + (5S,6S,10R)-10-(2-bromophenyl)-14-[(E)-1-(2-bromophenyl)methylidene]-3,9-diphenyl-12-(1-phenylethyl)-1,4,7-trioxa-2,8,12-triazadispiro[4.0.4.4]tetradeca-2,8-diene (1245653-73-9) + (4R,5S,6R,11R,15S)-4,15-bis(2-bromophenyl)-3,9,14-triphenyl-17-[(R)-1-phenylethyl]-1,7,10,12-tetraoxa-2,8,13,17-tetraazatrispiro[4.0.4.3]octadeca-2,8,13-triene (1245653-99-9)

Guidance literature:

With triethylamine; In benzene; at 20 ℃; diastereoselective reaction;

DOI:10.1016/j.tetasy.2010.03.054

Reference yield: 24.0%

3,5-bis[(E)-(2-bromophenyl)methylidene]-1-[(R)-1-phenylethyl]tetrahydro-4(1H)-pyridinone (1245653-62-6) + 4-chlorobenzohydroximoyl chloride (28123-63-9) → 4,11-bis(2-bromophenyl)-3,10-bis(4-chlorophenyl)-13-((R)-1-phenylethyl)-1,8-dioxa-2,9,13-triazadispiro[4.1.4.3]tetradeca-2,9-dien-6-one (1245740-91-3) + (5R,6R,10S)-10-(2-bromophenyl)-14-[(E)-1-(2-bromophenyl)methylidene]-3,9-di(4-chlorophenyl)-12-(1-phenylethyl)-1,4,7-trioxa-2,8,12-triazadispiro[4.0.4.4]-tetradeca-2,8-diene (1245653-90-0) + (5S,6S,10R)-10-(2-bromophenyl)-14-[(E)-1-(2-bromophenyl)methylidene]-3,9-di(4-chlorophenyl)-12-(1-phenylethyl)-1,4,7-trioxa-2,8,12-triazadispiro[4.0.4.4]-tetradeca-2,8-diene (1245653-74-0) + (4R,5S,6R,11R,15S)-4,15-bis(2-bromophenyl)-3,9,14-tri(4-chlorophenyl)-17-(1-phenylethyl)-1,7,10,12-tetraoxa-2,8,13,17-tetraazatrispiro[4.0.4.0.4.3]octadeca-2,8,13-triene (1245654-00-5)

Guidance literature:

With triethylamine; In benzene; at 20 ℃; diastereoselective reaction;

DOI:10.1016/j.tetasy.2010.03.054

upstream raw materials:

(R)-1-(1-phenylethyl)tetrahydro-4(1H)-pyridinone

ortho-bromobenzaldehyde

Downstream raw materials:

(5R,6R,10S)-10-(2-bromophenyl)-14-[(E)-1-(2-bromophenyl)methylidene]-3,9-diphenyl-12-(1-phenylethyl)-1,4,7-trioxa-2,8,12-triazadispiro[4.0.4.4]tetradeca-2,8-diene

(5S,6S,10R)-10-(2-bromophenyl)-14-[(E)-1-(2-bromophenyl)methylidene]-3,9-diphenyl-12-(1-phenylethyl)-1,4,7-trioxa-2,8,12-triazadispiro[4.0.4.4]tetradeca-2,8-diene

(4R,5S,6R,11R,15S)-4,15-bis(2-bromophenyl)-3,9,14-triphenyl-17-[(R)-1-phenylethyl]-1,7,10,12-tetraoxa-2,8,13,17-tetraazatrispiro[4.0.4.3]octadeca-2,8,13-triene

4,11-bis(2-bromophenyl)-3,10-bis(4-chlorophenyl)-13-((R)-1-phenylethyl)-1,8-dioxa-2,9,13-triazadispiro[4.1.4.3]tetradeca-2,9-dien-6-one

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