cyclohexanecarboxylic acid (2-methoxy-5-nitro-phenyl)-amide

Base Information

• Chemical Name: cyclohexanecarboxylic acid (2-methoxy-5-nitro-phenyl)-amide
• CAS No.: 313405-81-1
• Molecular Formula: C₁₄H₁₈N₂O₄
• Molecular Weight: 278.308
• Mol file: 313405-81-1.mol

Synonyms:cyclohexanecarboxylic acid (2-methoxy-5-nitro-phenyl)-amide

Chemical Property of cyclohexanecarboxylic acid (2-methoxy-5-nitro-phenyl)-amide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of cyclohexanecarboxylic acid (2-methoxy-5-nitro-phenyl)-amide

There total 1 articles about cyclohexanecarboxylic acid (2-methoxy-5-nitro-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclohexanylcarbonyl chloride (2719-27-9) + 3-amino-4-methoxynitrobenzene (99-59-2) → cyclohexanecarboxylic acid (2-methoxy-5-nitro-phenyl)-amide (313405-81-1)

Guidance literature:

With potassium carbonate; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/ja0567485

Reference yield:

cyclohexanecarboxylic acid (2-methoxy-5-nitro-phenyl)-amide (313405-81-1) → cyclohexanecarboxylic acid (5-amino-2-methoxy-phenyl)-amide (859179-67-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 12h;

DOI:10.1021/ja0567485

Reference yield:

cyclohexanecarboxylic acid (2-methoxy-5-nitro-phenyl)-amide (313405-81-1) → cyclohexanecarboxylic acid {2-methoxy-5-[6-(3-trifluoromethylphenylamino)-pyrimidin-4-ylamino]-phenyl}-amide

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / ethanol / 12 h / 20 °C

2: aq. HCl / butan-1-ol / 0.17 h / 160 °C / microwave irradiation

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; butan-1-ol;

DOI:10.1021/ja0567485

upstream raw materials:

cyclohexanylcarbonyl chloride

3-amino-4-methoxynitrobenzene

Downstream raw materials:

cyclohexanecarboxylic acid (5-amino-2-methoxy-phenyl)-amide