tert-butyl 2-(4-(3-fluoro-2-(2-methoxyphenyl)-1H-indol-5-yl)-5,6-dihydropyridin-1(2H)-yl)ethyl(methyl)carbamate

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Chemical Name:tert-butyl 2-(4-(3-fluoro-2-(2-methoxyphenyl)-1H-indol-5-yl)-5,6-dihydropyridin-1(2H)-yl)ethyl(methyl)carbamate
CAS No.:912971-39-2
Molecular Formula:C₂₈H₃₄FN₃O₃
Molecular Weight:479.595
Hs Code.:

Synonyms:tert-butyl 2-(4-(3-fluoro-2-(2-methoxyphenyl)-1H-indol-5-yl)-5,6-dihydropyridin-1(2H)-yl)ethyl(methyl)carbamate

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Chemical Property of tert-butyl 2-(4-(3-fluoro-2-(2-methoxyphenyl)-1H-indol-5-yl)-5,6-dihydropyridin-1(2H)-yl)ethyl(methyl)carbamate

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Technology Process of tert-butyl 2-(4-(3-fluoro-2-(2-methoxyphenyl)-1H-indol-5-yl)-5,6-dihydropyridin-1(2H)-yl)ethyl(methyl)carbamate

There total 2 articles about tert-butyl 2-(4-(3-fluoro-2-(2-methoxyphenyl)-1H-indol-5-yl)-5,6-dihydropyridin-1(2H)-yl)ethyl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1-(2-(tert-butoxycarbonyl(methyl)amino)ethyl)-1,2,3,6-tetrahydropyridin-4-yl trifluoromethanesulfonate

: 912971-37-0
3-fluoro-2-(2-methoxyphenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole

: 912971-39-2
tert-butyl 2-(4-(3-fluoro-2-(2-methoxyphenyl)-1H-indol-5-yl)-5,6-dihydropyridin-1(2H)-yl)ethyl(methyl)carbamate

Guidance literature:: With caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 100 ℃; Product distribution / selectivity;

Reference yield: 44.0%

: 912971-38-1
tert-butyl 4-(3-fluoro-2-(2-methoxyphenyl)-1H-indol-5-yl)-5,6-dihydropyridine-1(2H)-carboxylate

: 123387-72-4
O-tert-butyl N-methyl-N-(2-oxoethyl)carbamate

: 912971-39-2
tert-butyl 2-(4-(3-fluoro-2-(2-methoxyphenyl)-1H-indol-5-yl)-5,6-dihydropyridin-1(2H)-yl)ethyl(methyl)carbamate

Guidance literature:: tert-butyl 4-(3-fluoro-2-(2-methoxyphenyl)-1H-indol-5-yl)-5,6-dihydropyridine-1(2H)-carboxylate; With trifluoroacetic acid; In 1,1-dichloroethane; at 20 ℃; for 1h;

O-tert-butyl N-methyl-N-(2-oxoethyl)carbamate; With sodium tris(acetoxy)borohydride; acetic acid; In 1,1-dichloroethane; at 20 ℃;

With ammonia; In methanol; dichloromethane; water; Product distribution / selectivity;

Reference yield:

: 912971-39-2
tert-butyl 2-(4-(3-fluoro-2-(2-methoxyphenyl)-1H-indol-5-yl)-5,6-dihydropyridin-1(2H)-yl)ethyl(methyl)carbamate

: 912971-44-9
tert-butyl 2-(4-(3-fluoro-2-(2-methoxyphenyl)-1H-indol-5-yl)piperidin-1-yl)ethyl(methyl)carbamate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 3h; under 1551.49 Torr; Product distribution / selectivity;