123387-72-4 Usage
Description
N-BOC-(METHYLAMINO)ACETALDEHYDE is a colorless liquid that serves as a key intermediate in the synthesis of various organic compounds, particularly in the preparation of benzo[d]imidazole inhibitors.
Uses
Used in Pharmaceutical Industry:
N-BOC-(METHYLAMINO)ACETALDEHYDE is used as a chemical intermediate for the synthesis of benzo[d]imidazole inhibitors of co-activator associated arginine methyltransferase. These inhibitors play a crucial role in the development of potential therapeutic agents targeting various diseases by modulating protein-protein interactions and cellular signaling pathways.
Used in Organic Synthesis:
N-BOC-(METHYLAMINO)ACETALDEHYDE is utilized as a versatile building block in organic synthesis, enabling the creation of a wide range of chemical compounds with diverse applications across various industries, including pharmaceuticals, agrochemicals, and materials science. Its reactivity and functional group compatibility make it a valuable component in the development of new molecules with desired properties and functions.
Check Digit Verification of cas no
The CAS Registry Mumber 123387-72-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,3,8 and 7 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 123387-72:
(8*1)+(7*2)+(6*3)+(5*3)+(4*8)+(3*7)+(2*7)+(1*2)=124
124 % 10 = 4
So 123387-72-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H15NO3/c1-8(2,3)12-7(11)9(4)5-6-10/h6H,5H2,1-4H3
123387-72-4Relevant articles and documents
Synthesis and antimitotic/cytotoxic activity of hemiasterlin analogues
Nieman, James A.,Coleman, John E.,Wallace, Debra J.,Piers, Edward,Lim, Lynette Y.,Roberge, Michel,Andersen, Raymond J.
, p. 183 - 199 (2007/10/03)
The antimitotic sponge tripeptide hemiasterlin (1) and a number of structural analogues have been synthesized and evaluated in cell-based assays for both cytotoxic and antimitotic activity in order to explore the SAR for this promising anticancer drug lead. One synthetic analogue, SPA110 (8), showed more potent in vitro cytotoxicty and antimitotic activity than the natural product hemiasterlin (1), and consequently it has been subjected to thorough preclinical evaluation and targeted for clinical evaluation. The details of the synthesis of hemiasterlin (1) and the analogues and a discussion of how their biological activities vary with their structures are presented in this paper.