Technology Process of 6-(N3-(4-methoxyphenyl)ureido)saccharin
There total 5 articles about 6-(N3-(4-methoxyphenyl)ureido)saccharin which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-amino-1,2-benzisothiazole-3(2H)-one 1,1-dioxide; 4-Methoxyphenyl isocyanate;
With
triethylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 12h;
With
hydrogenchloride;
In
water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.03.033
- Guidance literature:
-
Multi-step reaction with 5 steps
1: chlorosulfonic acid / 20 h / 60 °C
2: ammonia / diethyl ether; water / 2.3 h / 10 - 40 °C
3: chromium(VI) oxide; sulfuric acid / water / 24 h / 20 °C
4: palladium 10% on activated carbon; cyclohexene / ethanol / 2 h / Reflux; Cooling with ice
5: triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C
With
chromium(VI) oxide; chlorosulfonic acid; sulfuric acid; palladium 10% on activated carbon; ammonia; triethylamine; cyclohexene;
In
diethyl ether; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.03.033
- Guidance literature:
-
Multi-step reaction with 3 steps
1: chromium(VI) oxide; sulfuric acid / water / 24 h / 20 °C
2: palladium 10% on activated carbon; cyclohexene / ethanol / 2 h / Reflux; Cooling with ice
3: triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C
With
chromium(VI) oxide; sulfuric acid; palladium 10% on activated carbon; triethylamine; cyclohexene;
In
ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.03.033