3-<(3-aminophenyl)cyclopropylmethyl>-4-hydroxy-7-methoxybenzopyran-2-one

Base Information

Chemical Name:3-<(3-aminophenyl)cyclopropylmethyl>-4-hydroxy-7-methoxybenzopyran-2-one
CAS No.:176771-76-9
Molecular Formula:C₂₀H₁₉NO₄
Molecular Weight:337.375
Hs Code.:

Synonyms:3-<(3-aminophenyl)cyclopropylmethyl>-4-hydroxy-7-methoxybenzopyran-2-one

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Chemical Property of 3-<(3-aminophenyl)cyclopropylmethyl>-4-hydroxy-7-methoxybenzopyran-2-one

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Technology Process of 3-<(3-aminophenyl)cyclopropylmethyl>-4-hydroxy-7-methoxybenzopyran-2-one

There total 6 articles about 3-<(3-aminophenyl)cyclopropylmethyl>-4-hydroxy-7-methoxybenzopyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3481-02-5
cyclopropyl phenyl ketone

: 176771-76-9
3-<(3-aminophenyl)cyclopropylmethyl>-4-hydroxy-7-methoxybenzopyran-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 50 percent / fuming 90percent nitric acid / 0.17 h / -10 °C

2: 1.) NaH / 1.) benzene, RT, 60 min, 2.) benzene, overnight

3: H₂ / 5percent Pt/C / methanol / 2585.7 Torr

4: diisopropylethylamine / CH₂Cl₂ / Ambient temperature

5: 1.) diisopropylamine, butyllithium / 1.) THF, hexane, -78 deg C, 50 min, 2.) THF, hexane, -78 deg C, 5 min

6: trifluoroacetic acid / 24 h / Ambient temperature

With n-butyllithium; hydrogen; nitric acid; sodium hydride; diisopropylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; platinum on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm00018a023

Reference yield:

: 5680-51-3
cyclopropyl-(3-nitrophenyl)methanone

: 176771-76-9
3-<(3-aminophenyl)cyclopropylmethyl>-4-hydroxy-7-methoxybenzopyran-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) benzene, RT, 60 min, 2.) benzene, overnight

2: H₂ / 5percent Pt/C / methanol / 2585.7 Torr

3: diisopropylethylamine / CH₂Cl₂ / Ambient temperature

4: 1.) diisopropylamine, butyllithium / 1.) THF, hexane, -78 deg C, 50 min, 2.) THF, hexane, -78 deg C, 5 min

5: trifluoroacetic acid / 24 h / Ambient temperature

With n-butyllithium; hydrogen; sodium hydride; diisopropylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; platinum on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm00018a023

Reference yield:

: (E)-3-Cyclopropyl-3-(3-nitro-phenyl)-acrylic acid tert-butyl ester

: 176771-76-9
3-<(3-aminophenyl)cyclopropylmethyl>-4-hydroxy-7-methoxybenzopyran-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 5percent Pt/C / methanol / 2585.7 Torr

2: diisopropylethylamine / CH₂Cl₂ / Ambient temperature

3: 1.) diisopropylamine, butyllithium / 1.) THF, hexane, -78 deg C, 50 min, 2.) THF, hexane, -78 deg C, 5 min

4: trifluoroacetic acid / 24 h / Ambient temperature

With n-butyllithium; hydrogen; diisopropylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; platinum on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm00018a023