(2R,3R)-N,N,N',N'-Tetramethyl-1,4,10,13-tetraoxa-7,16-ditosylazacyclooctadecane-2,3-dicarboxamide

Base Information

Chemical Name:(2R,3R)-N,N,N',N'-Tetramethyl-1,4,10,13-tetraoxa-7,16-ditosylazacyclooctadecane-2,3-dicarboxamide
CAS No.:130190-45-3
Molecular Formula:C₃₂H₄₈N₄O₁₀S₂
Molecular Weight:712.886
Hs Code.:

Synonyms:(2R,3R)-N,N,N',N'-Tetramethyl-1,4,10,13-tetraoxa-7,16-ditosylazacyclooctadecane-2,3-dicarboxamide

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Chemical Property of (2R,3R)-N,N,N',N'-Tetramethyl-1,4,10,13-tetraoxa-7,16-ditosylazacyclooctadecane-2,3-dicarboxamide

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Technology Process of (2R,3R)-N,N,N',N'-Tetramethyl-1,4,10,13-tetraoxa-7,16-ditosylazacyclooctadecane-2,3-dicarboxamide

There total 4 articles about (2R,3R)-N,N,N',N'-Tetramethyl-1,4,10,13-tetraoxa-7,16-ditosylazacyclooctadecane-2,3-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100190-98-5
(2R,3R)-N,N,N',N'-tetramethyl-2,3-bis<2-(tosyloxy)ethoxy>succinamide

: 19249-03-7
triethylene glycol di-(p-toluenesulfonate)

: 130190-45-3
(2R,3R)-N,N,N',N'-Tetramethyl-1,4,10,13-tetraoxa-7,16-ditosylazacyclooctadecane-2,3-dicarboxamide

Guidance literature:: With caesium carbonate; Yield given. Multistep reaction; 1.) DMF, 1,5 h, room temperature, 2.) DMF, 20 h, room temperature;

Reference yield:

: 26549-65-5
N,N,N',N'-tetramethyl L-tartramide

: 130190-45-3
(2R,3R)-N,N,N',N'-Tetramethyl-1,4,10,13-tetraoxa-7,16-ditosylazacyclooctadecane-2,3-dicarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) TlOEt / 1.) DMF, 50 deg C, 2.) 65 deg C, 14 h

2: conc. HCl / methanol / 1 h / Heating

3: NEt₃ / CH₂Cl₂ / 24 h / Ambient temperature

4: 1.) Cs₂CO₃ / 1.) DMF, 1,5 h, room temperature, 2.) DMF, 20 h, room temperature

With hydrogenchloride; thallium (I) ethoxide; caesium carbonate; triethylamine; In methanol; dichloromethane;

Reference yield:

: 100190-95-2
(2R,3R)-N,N,N',N'-Tetramethyl-2,3-bis(2-hydroxyethyl)succinamide

: 130190-45-3
(2R,3R)-N,N,N',N'-Tetramethyl-1,4,10,13-tetraoxa-7,16-ditosylazacyclooctadecane-2,3-dicarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: NEt₃ / CH₂Cl₂ / 24 h / Ambient temperature

2: 1.) Cs₂CO₃ / 1.) DMF, 1,5 h, room temperature, 2.) DMF, 20 h, room temperature

With caesium carbonate; triethylamine; In dichloromethane;