Technology Process of 12-(p-vinyl)homobenzyldeoxoartemisinin
There total 4 articles about 12-(p-vinyl)homobenzyldeoxoartemisinin which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
12-(p-vinyl)homobenzyldihydroartemisinyl alcohol;
With
oxygen; rose bengal;
In
dichloromethane; acetonitrile;
at -40 ℃;
for 4h;
Irradiation;
With
oxygen; trifluoroacetic acid;
In
acetonitrile;
at -40 ℃;
for 2h;
Further stages.;
DOI:10.1021/jm020244p
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: diethyl ether / 3 h / 20 °C
2.1: NaBH4; NiCl2*6H2O / methanol / 0.5 h / 0 °C
3.1: DIBAL-H / CH2Cl2 / 1 h / -78 °C
4.1: 76 percent / KOH / dimethylsulfoxide / 2 h / 20 °C
5.1: Mg
5.2: 81 percent / diethyl ether / 12 h / 0 °C
6.1: O2; rose bengal / CH2Cl2; acetonitrile / 4 h / -40 °C / Irradiation
6.2: 35 percent / TFA; O2 / acetonitrile / 2 h / -40 °C
With
potassium hydroxide; sodium tetrahydroborate; oxygen; rose bengal; diisobutylaluminium hydride; magnesium; nickel dichloride;
In
methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jm020244p
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: NaBH4; NiCl2*6H2O / methanol / 0.5 h / 0 °C
2.1: DIBAL-H / CH2Cl2 / 1 h / -78 °C
3.1: 76 percent / KOH / dimethylsulfoxide / 2 h / 20 °C
4.1: Mg
4.2: 81 percent / diethyl ether / 12 h / 0 °C
5.1: O2; rose bengal / CH2Cl2; acetonitrile / 4 h / -40 °C / Irradiation
5.2: 35 percent / TFA; O2 / acetonitrile / 2 h / -40 °C
With
potassium hydroxide; sodium tetrahydroborate; oxygen; rose bengal; diisobutylaluminium hydride; magnesium; nickel dichloride;
In
methanol; dichloromethane; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jm020244p
