piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-{4-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethoxycarbonyl]-phenyl} ester

Base Information

Chemical Name:piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-{4-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethoxycarbonyl]-phenyl} ester
CAS No.:262299-33-2
Molecular Formula:C₂₅H₃₅N₃O₇
Molecular Weight:489.569
Hs Code.:

piperidine-1,4-dicarboxylic acid 1-<i>tert</i>-butyl ester 4-{4-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethoxycarbonyl]-phenyl} ester

Synonyms:piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-{4-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethoxycarbonyl]-phenyl} ester

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Chemical Property of piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-{4-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethoxycarbonyl]-phenyl} ester

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Technology Process of piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-{4-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethoxycarbonyl]-phenyl} ester

There total 5 articles about piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-{4-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethoxycarbonyl]-phenyl} ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 262298-71-5
4-hydroxy-benzoic acid 2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl ester

: 262299-33-2
piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-{4-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethoxycarbonyl]-phenyl} ester

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; acetonitrile; at -20 - 20 ℃;
DOI:10.1016/S0223-5234(99)00123-3

Reference yield:

: 498-94-2
isonipecotic acid

: 262299-33-2
piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-{4-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethoxycarbonyl]-phenyl} ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / Na₂CO₃ / H₂O; dioxane / 20 °C

2: 56 percent / dicyclohexylcarbodiimide / CH₂Cl₂; acetonitrile / -20 - 20 °C

With sodium carbonate; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; water; acetonitrile; 1: Substitution / 2: Esterification;
DOI:10.1016/S0223-5234(99)00123-3

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 262299-33-2
piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-{4-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethoxycarbonyl]-phenyl} ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / Na₂CO₃ / H₂O; dioxane / 20 °C

2: 56 percent / dicyclohexylcarbodiimide / CH₂Cl₂; acetonitrile / -20 - 20 °C

With sodium carbonate; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; water; acetonitrile; 1: Substitution / 2: Esterification;
DOI:10.1016/S0223-5234(99)00123-3