methyl <1(R/S)-(N-CBZ-amino)-2-phenylethyl>methylphosphinate

Base Information

• Chemical Name: methyl <1(R/S)-(N-CBZ-amino)-2-phenylethyl>methylphosphinate
• CAS No.: 156336-14-0
• Molecular Formula: C₁₈H₂₂NO₄P
• Molecular Weight: 347.351
• Mol file: 156336-14-0.mol

Synonyms:methyl <1(R/S)-(N-CBZ-amino)-2-phenylethyl>methylphosphinate

Chemical Property of methyl <1(R/S)-(N-CBZ-amino)-2-phenylethyl>methylphosphinate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of methyl <1(R/S)-(N-CBZ-amino)-2-phenylethyl>methylphosphinate

There total 1 articles about methyl <1(R/S)-(N-CBZ-amino)-2-phenylethyl>methylphosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1-Benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinic acid methyl ester (126410-33-1) + methyl iodide (74-88-4) → methyl <1(R/S)-(N-CBZ-amino)-2-phenylethyl>methylphosphinate (156336-14-0)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) THF, RT, 30 min, 2.) THF, RT, 3 h;

DOI:10.1021/ja00094a003

Reference yield: 87.0%

methyl <1(R/S)-(N-CBZ-amino)-2-phenylethyl>methylphosphinate (156336-14-0) → <1(R/S)-(N-CBZ-amino)-2-phenylethyl>methylphosphinic acid (119012-13-4)

Guidance literature:

With lithium hydroxide; In 1,4-dioxane; water; for 48h; Ambient temperature;

DOI:10.1021/ja00094a003

Reference yield:

methyl <1(R/S)-(N-CBZ-amino)-2-phenylethyl>methylphosphinate (156336-14-0) → (1-Amino-2-phenyl-ethyl)-methyl-phosphinic acid (107016-45-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / aq. LiOH / dioxane; H₂O / 48 h / Ambient temperature

2: 40 mg / H₂ / 10percent Pd/C / methanol / 4 h / Ambient temperature

With lithium hydroxide; hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol; water;

DOI:10.1021/ja00094a003

upstream raw materials:

(1-Benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinic acid methyl ester

methyl iodide

Downstream raw materials:

<1(R/S)-(N-CBZ-amino)-2-phenylethyl>methylphosphinic acid

(1-Amino-2-phenyl-ethyl)-methyl-phosphinic acid