8-(2-(1H-imidazol-1-yl)-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:8-(2-(1H-imidazol-1-yl)-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline
CAS No.:1454667-39-0
Molecular Formula:C₁₉H₁₆F₃N₃
Molecular Weight:343.351
Hs Code.:

Synonyms:8-(2-(1H-imidazol-1-yl)-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-(2-(1H-imidazol-1-yl)-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:

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Technology Process of 8-(2-(1H-imidazol-1-yl)-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

There total 2 articles about 8-(2-(1H-imidazol-1-yl)-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443377-25-0
1-(2-bromo-5-(trifluoromethyl)phenyl)-1H-imidazole

: 371766-08-4
isoquinoline 5-boronic acid

: 1454667-39-0
8-(2-(1H-imidazol-1-yl)-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: 1-(2-bromo-5-(trifluoromethyl)phenyl)-1H-imidazole; isoquinoline 5-boronic acid; With potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In 1,4-dioxane; water; at 120 ℃;

With platinum(IV) oxide; hydrogen; acetic acid; In methanol; for 2h; under 2327.23 Torr;

Reference yield:

: 40161-54-4
1-bromo-2-fluoro-4-(trifluoromethyl)benzene

: 1454667-39-0
8-(2-(1H-imidazol-1-yl)-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 150 °C / Microwave irradiation

2.1: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; 1,4-dioxane / 120 °C

2.2: 2 h / 2327.23 Torr

With potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium tert-butylate; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 7552-07-0
1,3,4-thiadiazol-5-amine

: 1454667-39-0
8-(2-(1H-imidazol-1-yl)-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline

: 1454666-52-4
5-(2-(1H-imidazol-1-yl)-4-(trifluoromethyl)phenyl)-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydroisoquinoline-2(1H)-sulfonamide

Guidance literature:: 1,3,4-thiadiazol-5-amine; With sulfuryl dichloride; triethylamine; In dichloromethane; at -78 ℃;

8-(2-(1H-imidazol-1-yl)-4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline; In dichloromethane; for 1h;