N-(4-{[2-(aminocarbonyl)pyridin-4-yl]oxy}-2,3-difluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxyamide

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Chemical Name:N-(4-{[2-(aminocarbonyl)pyridin-4-yl]oxy}-2,3-difluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxyamide
CAS No.:928038-50-0
Molecular Formula:C₂₃H₁₇F₃N₄O₄
Molecular Weight:470.408
Hs Code.:

Synonyms:N-(4-{[2-(aminocarbonyl)pyridin-4-yl]oxy}-2,3-difluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxyamide

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Chemical Property of N-(4-{[2-(aminocarbonyl)pyridin-4-yl]oxy}-2,3-difluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxyamide

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Technology Process of N-(4-{[2-(aminocarbonyl)pyridin-4-yl]oxy}-2,3-difluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxyamide

There total 3 articles about N-(4-{[2-(aminocarbonyl)pyridin-4-yl]oxy}-2,3-difluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxyamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 868735-84-6
4-(4-amino-2,3-difluorophenoxy)picolinamide

: 928038-50-0
N-(4-{[2-(aminocarbonyl)pyridin-4-yl]oxy}-2,3-difluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxyamide

Guidance literature:: ((4-fluorophenyl)carbamoyl)cyclopropanecarboxylic acid; With 4-methyl-morpholine; In tetrahydrofuran; at 0 ℃; for 0.25h;

With thionyl chloride; In tetrahydrofuran; at 0 ℃; for 0.583333h;

4-(4-amino-2,3-difluorophenoxy)picolinamide; With 4-methyl-morpholine; In tetrahydrofuran; at 20 ℃; for 28.3333h;

Reference yield:

: 99586-65-9
4-chloropicolinamide

: 928038-50-0
N-(4-{[2-(aminocarbonyl)pyridin-4-yl]oxy}-2,3-difluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxyamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h / 20 °C

1.2: 20 h / 80 - 100 °C

2.1: 4-methyl-morpholine / tetrahydrofuran / 0.25 h / 0 °C

2.2: 0.58 h / 0 °C

2.3: 28.33 h / 20 °C

With 4-methyl-morpholine; potassium tert-butylate; In tetrahydrofuran; dimethyl sulfoxide;

Reference yield:

: 163733-99-1
4-amino-2,3-difluoro-phenol

: 928038-50-0
N-(4-{[2-(aminocarbonyl)pyridin-4-yl]oxy}-2,3-difluorophenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxyamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h / 20 °C

1.2: 20 h / 80 - 100 °C

2.1: 4-methyl-morpholine / tetrahydrofuran / 0.25 h / 0 °C

2.2: 0.58 h / 0 °C

2.3: 28.33 h / 20 °C

With 4-methyl-morpholine; potassium tert-butylate; In tetrahydrofuran; dimethyl sulfoxide;