99586-65-9

Basic information

• Product Name: 4-Chloropyridine-2-carboxamide
• Synonyms: 4-Chloro-2-picolinamide;4-Chloropyridine-2-carboxamide ,95%;4-Chloropyridine-2-c;2-PyridinecarboxaMide,4-chloro;4-Chloropicolinamide, 2-Carbamoyl-4-chloropyridine;IFLAB-BB F2108-0034;4-CHLOROPICOLINAMIDE;4-CHLORO-PYRIDINE-2-CARBOXYLIC ACID AMIDE
• CAS NO: 99586-65-9
• Molecular Formula: C₆H₅ClN₂O
• Molecular Weight: 156.57
• Product Categories: NULL;blocks;Carboxes;Pyridines;Pyridine series;Pyridine
• Mol File: 99586-65-9.mol
• Article Data: 41

Chemical Properties

• Melting Point: 148-152
• Boiling Point: 298.1 °C at 760 mmHg
• Flash Point: 134.1 °C
• Appearance: Off-white/Solid
• Density: 1.381 g/cm³
• Vapor Pressure: 0.0013mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 14.49±0.50(Predicted)
• CAS DataBase Reference: 4-Chloropyridine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloropyridine-2-carboxamide(99586-65-9)
• EPA Substance Registry System: 4-Chloropyridine-2-carboxamide(99586-65-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 99586-65-9(Hazardous Substances Data)

Usage

Uses

4-Chloropyridine-2-carboxamide, is a versatile building block used in synthesis of various chemical compounds.

InChI:InChI=1/C6H5ClN2O/c7-4-1-2-9-5(3-4)6(8)10/h1-3H,(H2,8,10)

Upstream product

• 53750-66-6 4-chloro-pyridine-2-carbonyl chloride 
• 626-61-9 4-Chloropyridine 
• 77287-34-4 formamide 
• 176977-85-8 methyl 4-chloro-2-pyridinecarboxylate hydrochloride 
• 636-80-6 2-picolinic acid hydrochloride 
• 150009-83-9 3-Amino-2-methoxyquinoline 
• 51727-15-2 4-chloro-2-pyridine carboxylic acid chloride hydrochloride 
• 284462-89-1 4-(2-(N-isopropylcarbamoyl)-pyridin-4-yloxy)aniline 
• 284462-37-9 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide 
• 327-78-6 4-chloro-3-(trifluoromethyl)phenyl isocyanate 
• 349-65-5 2-Methoxy-5-trifluoromethyl-aniline 
• 75-44-5 phosgene 
• 284462-78-8 4-(3-aminophenoxy)-N-methylpicolinamide 
• 24484-93-3 4-Chloro-pyridine-2-carboxylic acid methyl ester 

Downstream Products

• 757251-54-0 4-(4-amino-3-fluorophenoxy)pyridine-2-carboxyamide 
• 928038-30-6 4-(3-Fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl] amino }phenoxy)pyridine-2-carboxamide 
• 868736-13-4 4-(4-amino-2,5-difluorophenoxy)picolinamide 
• 868735-84-6 4-(4-amino-2,3-difluorophenoxy)picolinamide 
• 868735-85-7 4-(6-amino-2,3-diflurophenoxy)pyridine-2-carboxamide 
• 930576-23-1 4-(2-carbamoylpyridin-4-yloxy)-3-fluorobenzoic acid 

Relevant articles and documents

Synthesis method of imidazopyridine or pyrimidine derivative

The invention belongs to the technical field of synthesis, and particularly relates to a synthesis method of an imidazopyridine or pyrimidine derivative. The imidazopyridine or pyrimidine compound is obtained by taking pyridine or pyrimidinecarboxylic acid as a synthon through amidation, Hofmann degradation and cyclization reaction, and the obtained imidazopyridine or pyrimidine derivative can be further converted to generate a functional product. The method has the advantages of easily available raw materials, simple operation, high reaction efficiency, convenient post-treatment, and diversity of functional groups.

Synthesis method of Tucatinib and intermediate product thereof

The invention discloses a synthesis method of Tucatinib, and the method comprises the following step: carrying out substitution reaction on halate of a compound shown in a formula VI or free alkali thereof serving as a raw material and a compound shown in a formula VII under an alkaline condition to obtain a compound shown in a formula VIII. The raw materials used in the whole synthesis route areeasy to obtain, expensive catalysts are not needed, and the method is suitable for large-scale production and beneficial to industrial production of the Tucatinib.

Transition-metal-free synthesis of primary to tertiary carboxamides: A quick access to prodrug-pyrazinecarboxamide

One-pot expedient and direct carbamoylation of heterocyclics is described. The transformation is realized via direct dehydrogenative aminocarbonylation of heterocyclic compounds under transition-metal-free conditions. This method is regioselective and the protocol is proved to be scalable on a gram scale. Further, the therapeutically useful antitubercular agent pyrazinecarboxamide is successfully synthesized by employing this protocol.