(3aS,6aR)-4-Benzenesulfonyl-1-(toluene-4-sulfonyl)-6-vinylidene-hexahydro-cyclopenta[b]pyrrol-2-one

Base Information

Chemical Name:(3aS,6aR)-4-Benzenesulfonyl-1-(toluene-4-sulfonyl)-6-vinylidene-hexahydro-cyclopenta[b]pyrrol-2-one
CAS No.:201014-32-6
Molecular Formula:C₂₂H₂₁NO₅S₂
Molecular Weight:443.544
Hs Code.:

Synonyms:(3aS,6aR)-4-Benzenesulfonyl-1-(toluene-4-sulfonyl)-6-vinylidene-hexahydro-cyclopenta[b]pyrrol-2-one

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Chemical Property of (3aS,6aR)-4-Benzenesulfonyl-1-(toluene-4-sulfonyl)-6-vinylidene-hexahydro-cyclopenta[b]pyrrol-2-one

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Technology Process of (3aS,6aR)-4-Benzenesulfonyl-1-(toluene-4-sulfonyl)-6-vinylidene-hexahydro-cyclopenta[b]pyrrol-2-one

There total 5 articles about (3aS,6aR)-4-Benzenesulfonyl-1-(toluene-4-sulfonyl)-6-vinylidene-hexahydro-cyclopenta[b]pyrrol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 34097-60-4
methyl benzenesulfonylacetate

: 201014-32-6
(3aS,6aR)-4-Benzenesulfonyl-1-(toluene-4-sulfonyl)-6-vinylidene-hexahydro-cyclopenta[b]pyrrol-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / triethylamine / dimethylformamide

2: 80 percent / NaH / dimethylformamide / 18 h / Ambient temperature

3: 80 percent / formic acid / dimethylformamide

4: 1.) LiOH, 2.) pyridine / 1.) THF, H₂O, 2.) 90 deg C

5: 1.) nBuLi / 1.) -78 deg C, 2 h, 2.) -78 deg C - 20 deg C

With pyridine; lithium hydroxide; n-butyllithium; formic acid; sodium hydride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jo971854d

Reference yield:

: 201014-16-6
((2R,3S)-1-Acetyl-2-isopropoxy-5-oxo-pyrrolidin-3-yl)-benzenesulfonyl-acetic acid methyl ester

: 201014-32-6
(3aS,6aR)-4-Benzenesulfonyl-1-(toluene-4-sulfonyl)-6-vinylidene-hexahydro-cyclopenta[b]pyrrol-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / NaH / dimethylformamide / 18 h / Ambient temperature

2: 80 percent / formic acid / dimethylformamide

3: 1.) LiOH, 2.) pyridine / 1.) THF, H₂O, 2.) 90 deg C

4: 1.) nBuLi / 1.) -78 deg C, 2 h, 2.) -78 deg C - 20 deg C

With pyridine; lithium hydroxide; n-butyllithium; formic acid; sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1021/jo971854d

Reference yield:

: 201014-21-3
2-((2R,3S)-1-Acetyl-2-isopropoxy-5-oxo-pyrrolidin-3-yl)-2-benzenesulfonyl-6-trimethylsilanyl-hex-4-ynoic acid methyl ester

: 201014-32-6
(3aS,6aR)-4-Benzenesulfonyl-1-(toluene-4-sulfonyl)-6-vinylidene-hexahydro-cyclopenta[b]pyrrol-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / formic acid / dimethylformamide

2: 1.) LiOH, 2.) pyridine / 1.) THF, H₂O, 2.) 90 deg C

3: 1.) nBuLi / 1.) -78 deg C, 2 h, 2.) -78 deg C - 20 deg C

With pyridine; lithium hydroxide; n-butyllithium; formic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jo971854d