4-[(3-Chlorophenyl)methyl]-1-piperazinepropanol

Base Information

Chemical Name:4-[(3-Chlorophenyl)methyl]-1-piperazinepropanol
CAS No.:739328-89-3
Molecular Formula:C₁₄H₂₁ClN₂O
Molecular Weight:268.787
Hs Code.:
DSSTox Substance ID:DTXSID701241872

Synonyms:4-[(3-Chlorophenyl)methyl]-1-piperazinepropanol;DTXSID701241872;AKOS033012266;739328-89-3;Z106042318

Suppliers and Price of 4-[(3-Chlorophenyl)methyl]-1-piperazinepropanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[(3-Chlorophenyl)methyl]-1-piperazinepropanol

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:268.1342410
Heavy Atom Count:18
Complexity:232

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCN1CCCO)CC2=CC(=CC=C2)Cl

Technology Process of 4-[(3-Chlorophenyl)methyl]-1-piperazinepropanol

There total 1 articles about 4-[(3-Chlorophenyl)methyl]-1-piperazinepropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23145-91-7
1-(3-chlorobenzyl)piperazine

: 627-18-9
1-bromo-3-propanol

: 739328-89-3
3-[4-(3-Chloro-benzyl)-piperazin-1-yl]-propan-1-ol

Guidance literature:: With potassium carbonate; In butanone; Heating;
DOI:10.1021/jm00161a022

Reference yield:

: 739328-89-3
3-[4-(3-Chloro-benzyl)-piperazin-1-yl]-propan-1-ol

: 104131-31-9
6-{3-[4-(3-Chloro-benzyl)-piperazin-1-yl]-propoxy}-5-methyl-1H-4-oxa-1,2,3-triaza-cyclopenta[b]naphthalen-9-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) K₂CO₃, 2.) diethyl azodicarboxylate, Ph₃P / 1.) DMF, RT, 24 h, 2.) THF, RT, 1.5 h

2: 68 percent / CF₃CO₂H / 65 °C

With potassium carbonate; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate;
DOI:10.1021/jm00161a022

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 79572-25-1
6-hydroxy-5-methyl<1>benzopyrano<2,3-d>-1,2,3-triazol-9(1H)-one

: 739328-89-3
3-[4-(3-Chloro-benzyl)-piperazin-1-yl]-propan-1-ol

: 104131-29-5
6-{3-[4-(3-Chloro-benzyl)-piperazin-1-yl]-propoxy}-1-(4-methoxy-benzyl)-5-methyl-1H-4-oxa-1,2,3-triaza-cyclopenta[b]naphthalen-9-one

: 104131-30-8
6-{3-[4-(3-Chloro-benzyl)-piperazin-1-yl]-propoxy}-2-(4-methoxy-benzyl)-5-methyl-2H-4-oxa-1,2,3-triaza-cyclopenta[b]naphthalen-9-one

Guidance literature:: With potassium carbonate; triphenylphosphine; diethylazodicarboxylate; Multistep reaction; 1.) DMF, RT, 24 h, 2.) THF, RT, 1.5 h;
DOI:10.1021/jm00161a022