(S)-N-[[3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]methyldithiocarbamate

Base Information

• Chemical Name: (S)-N-[[3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]methyldithiocarbamate
• CAS No.: 216868-96-1
• Molecular Formula: C₁₆H₂₀FN₃O₃S₂
• Molecular Weight: 385.484
• Mol file: 216868-96-1.mol

Synonyms:(S)-N-[[3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]methyldithiocarbamate

Chemical Property of (S)-N-[[3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]methyldithiocarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-[[3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]methyldithiocarbamate

There total 8 articles about (S)-N-[[3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]methyldithiocarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

carbon disulfide (75-15-0,12122-00-8) + (S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine (168828-90-8) + methyl iodide (74-88-4) → (S)-N-[[3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]methyldithiocarbamate (216868-96-1)

Guidance literature:

carbon disulfide; (S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine; With triethylamine; In ethanol; water; at 20 ℃; for 20h; Cooling with ice;

methyl iodide; In ethanol; water; at 20 ℃; for 1.5h;

Reference yield:

3-fluoro-4-(4-morpholinyl)nitrobenzene (2689-39-6) → (S)-N-[[3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]methyldithiocarbamate (216868-96-1)

Guidance literature:

Multi-step reaction with 7 steps

1: H₂ / PtO₂ / methanol / 3 h / 20 °C / 1471.02 Torr

2: Et₃N / tetrahydrofuran / 2 h / 20 °C

3: sodium azide / dimethylformamide / 6 h / 65 °C

4: triphenylphosphine; H₂O / tetrahydrofuran / 11 h / 40 °C

5: Et₃N / tetrahydrofuran / 7 h / 0 °C

6: Et₃N / tetrahydrofuran / 0.5 h / 20 °C

With sodium azide; water; hydrogen; triethylamine; triphenylphosphine; platinum(IV) oxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.49.353

Reference yield:

[(S)-3-(3-Fluoro-4-morpholin-4-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-dithiocarbamic acid + methyl iodide (74-88-4) → (S)-N-[[3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]methyldithiocarbamate (216868-96-1)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1248/cpb.49.353

upstream raw materials:

methyl iodide

3-fluoro-4-(4-morpholinyl)nitrobenzene

3-fluoro-4-(morpholinyl)aniline

(R)-3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl methanol