8-[1-(3,5-difluorophenyl)pyrrolidin-2-yl]-2-morpholino-6-[(1-oxidothiomorpholin-4-yl)carbonyl]-4H-chromen-4-one

Base Information

• Chemical Name: 8-[1-(3,5-difluorophenyl)pyrrolidin-2-yl]-2-morpholino-6-[(1-oxidothiomorpholin-4-yl)carbonyl]-4H-chromen-4-one
• CAS No.: 1403458-29-6
• Molecular Formula: C₂₈H₂₉F₂N₃O₅S
• Molecular Weight: 557.618

Synonyms:8-[1-(3,5-difluorophenyl)pyrrolidin-2-yl]-2-morpholino-6-[(1-oxidothiomorpholin-4-yl)carbonyl]-4H-chromen-4-one

Chemical Property of 8-[1-(3,5-difluorophenyl)pyrrolidin-2-yl]-2-morpholino-6-[(1-oxidothiomorpholin-4-yl)carbonyl]-4H-chromen-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-[1-(3,5-difluorophenyl)pyrrolidin-2-yl]-2-morpholino-6-[(1-oxidothiomorpholin-4-yl)carbonyl]-4H-chromen-4-one

There total 13 articles about 8-[1-(3,5-difluorophenyl)pyrrolidin-2-yl]-2-morpholino-6-[(1-oxidothiomorpholin-4-yl)carbonyl]-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-2-morpholino-4-oxo-4H-chromene-6-carboxylic acid (1403458-62-7) + 1λ1-thiomorpholin-1-one hydrochloride (76176-87-9) → 8-[1-(3,5-difluorophenyl)pyrrolidin-2-yl]-2-morpholino-6-[(1-oxidothiomorpholin-4-yl)carbonyl]-4H-chromen-4-one (1403458-29-6)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 5.5h;

Reference yield:

methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) → 8-[1-(3,5-difluorophenyl)pyrrolidin-2-yl]-2-morpholino-6-[(1-oxidothiomorpholin-4-yl)carbonyl]-4H-chromen-4-one (1403458-29-6)

Guidance literature:

Multi-step reaction with 10 steps

1.1: bromine / dichloromethane / 36 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine / palladium diacetate; 1,1'-bis(diphenylphosphino)ferrocene / ethanol / 70 °C / Inert atmosphere

3.1: bromine; pyridine / dichloromethane / 2 h / 0 - 20 °C

4.1: trifluoroborane diethyl ether / toluene / 20 °C / Inert atmosphere

4.2: 12 h / 90 °C

5.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 7 h / 80 °C / Inert atmosphere

6.1: hydrogen / 5% rhodium on activated aluminium oxide / methanol / 7 h / 65 °C / 3750.38 Torr

7.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

8.1: caesium carbonate / Palladium complex / 1,4-dioxane / 23 h / 80 °C / Inert atmosphere

9.1: sodium hydroxide; water / methanol / 6 h / 40 °C

9.2: 0 °C / pH 5

10.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / 5.5 h / 20 °C

With pyridine; hydrogenchloride; water; hydrogen; bromine; trifluoroborane diethyl ether; sodium carbonate; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; 1,1'-bis(diphenylphosphino)ferrocene; 5% rhodium on activated aluminium oxide; palladium diacetate; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; toluene;

Reference yield:

methyl 3-acetyl-4-hydroxybenzoate (57009-12-8) → 8-[1-(3,5-difluorophenyl)pyrrolidin-2-yl]-2-morpholino-6-[(1-oxidothiomorpholin-4-yl)carbonyl]-4H-chromen-4-one (1403458-29-6)

Guidance literature:

Multi-step reaction with 8 steps

1.1: bromine; pyridine / dichloromethane / 2 h / 0 - 20 °C

2.1: trifluoroborane diethyl ether / toluene / 20 °C / Inert atmosphere

2.2: 12 h / 90 °C

3.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 7 h / 80 °C / Inert atmosphere

4.1: hydrogen / 5% rhodium on activated aluminium oxide / methanol / 7 h / 65 °C / 3750.38 Torr

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C

6.1: caesium carbonate / Palladium complex / 1,4-dioxane / 23 h / 80 °C / Inert atmosphere

7.1: sodium hydroxide; water / methanol / 6 h / 40 °C

7.2: 0 °C / pH 5

8.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / 5.5 h / 20 °C

With pyridine; hydrogenchloride; water; hydrogen; bromine; trifluoroborane diethyl ether; sodium carbonate; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; 5% rhodium on activated aluminium oxide; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene;

upstream raw materials:

methyl 4-hydroxylbenzoate

methyl 3-bromo-4-hydroxybenzoate

4-(dichloromethylene)morpholin-4-ium chloride

methyl 3-acetyl-4-hydroxybenzoate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1403458-29-6 8-[1-(3,5-difluorophenyl)pyrrolidin-2-yl]-2-morpholino-6-[(1-oxidothiomorpholin-4-yl)carbonyl]-4H-chromen-4-one

Send

Send

Metric Ton KG G Pound L ML

Send

Send