Technology Process of 8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-2-morpholino-4-oxo-4H-chromene-6-carboxylic acid
There total 12 articles about 8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-2-morpholino-4-oxo-4H-chromene-6-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-2-morpholino-4-oxo-4H-chromene-6-carboxylate;
With
water; sodium hydroxide;
In
methanol;
at 40 ℃;
for 6h;
With
hydrogenchloride;
In
methanol; water;
at 0 ℃;
pH=5;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: triethylamine / palladium diacetate; 1,1'-bis(diphenylphosphino)ferrocene / ethanol / 70 °C / Inert atmosphere
2.1: bromine; pyridine / dichloromethane / 2 h / 0 - 20 °C
3.1: trifluoroborane diethyl ether / toluene / 20 °C / Inert atmosphere
3.2: 12 h / 90 °C
4.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 7 h / 80 °C / Inert atmosphere
5.1: hydrogen / 5% rhodium on activated aluminium oxide / methanol / 7 h / 65 °C / 3750.38 Torr
6.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C
7.1: caesium carbonate / Palladium complex / 1,4-dioxane / 23 h / 80 °C / Inert atmosphere
8.1: sodium hydroxide; water / methanol / 6 h / 40 °C
8.2: 0 °C / pH 5
With
pyridine; hydrogenchloride; water; hydrogen; bromine; trifluoroborane diethyl ether; sodium carbonate; caesium carbonate; triethylamine; sodium hydroxide;
bis-triphenylphosphine-palladium(II) chloride; 1,1'-bis(diphenylphosphino)ferrocene; 5% rhodium on activated aluminium oxide; palladium diacetate;
In
1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: thionyl chloride / 3 h / 80 °C / Inert atmosphere
2.1: trifluoroborane diethyl ether / toluene / 20 °C / Inert atmosphere
2.2: 12 h / 90 °C
3.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 7 h / 80 °C / Inert atmosphere
4.1: hydrogen / 5% rhodium on activated aluminium oxide / methanol / 7 h / 65 °C / 3750.38 Torr
5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 4 h / 20 °C
6.1: caesium carbonate / Palladium complex / 1,4-dioxane / 23 h / 80 °C / Inert atmosphere
7.1: sodium hydroxide; water / methanol / 6 h / 40 °C
7.2: 0 °C / pH 5
With
hydrogenchloride; thionyl chloride; water; hydrogen; trifluoroborane diethyl ether; sodium carbonate; caesium carbonate; sodium hydroxide;
bis-triphenylphosphine-palladium(II) chloride; 5% rhodium on activated aluminium oxide;
In
1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene;
