(E)-3-{5-[(2,4-diamino-5-pyrimidinyl)methyl]-2,3-dimethoxyphenyl}-1-[1-(2-methylphenyl)-2(1H)-phthalazinyl]-2-prop-2-en-1-one

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Chemical Name:(E)-3-{5-[(2,4-diamino-5-pyrimidinyl)methyl]-2,3-dimethoxyphenyl}-1-[1-(2-methylphenyl)-2(1H)-phthalazinyl]-2-prop-2-en-1-one
CAS No.:1394153-21-9
Molecular Formula:C₃₁H₃₀N₆O₃
Molecular Weight:534.618
Hs Code.:

Synonyms:(E)-3-{5-[(2,4-diamino-5-pyrimidinyl)methyl]-2,3-dimethoxyphenyl}-1-[1-(2-methylphenyl)-2(1H)-phthalazinyl]-2-prop-2-en-1-one

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Chemical Property of (E)-3-{5-[(2,4-diamino-5-pyrimidinyl)methyl]-2,3-dimethoxyphenyl}-1-[1-(2-methylphenyl)-2(1H)-phthalazinyl]-2-prop-2-en-1-one

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Technology Process of (E)-3-{5-[(2,4-diamino-5-pyrimidinyl)methyl]-2,3-dimethoxyphenyl}-1-[1-(2-methylphenyl)-2(1H)-phthalazinyl]-2-prop-2-en-1-one

There total 5 articles about (E)-3-{5-[(2,4-diamino-5-pyrimidinyl)methyl]-2,3-dimethoxyphenyl}-1-[1-(2-methylphenyl)-2(1H)-phthalazinyl]-2-prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1394153-28-6
1-[1-(2-methylphenyl)-2(1H)-phthalazinyl]-2-propen-1-one

: 83166-73-8
5-(3-iodo-4,5-dimethoxy-benzyl)-pyrimidine-2,4-diamine

: 1394153-21-9
(E)-3-{5-[(2,4-diamino-5-pyrimidinyl)methyl]-2,3-dimethoxyphenyl}-1-[1-(2-methylphenyl)-2(1H)-phthalazinyl]-2-prop-2-en-1-one

Guidance literature:: With 1-ethyl-piperidine; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 140 ℃; for 18h; Inert atmosphere; sealed tube;
DOI:10.1016/j.ejmech.2012.05.018

Reference yield:

: 932-31-0
ortho-tolylmagnesium bromide

: 1394153-21-9
(E)-3-{5-[(2,4-diamino-5-pyrimidinyl)methyl]-2,3-dimethoxyphenyl}-1-[1-(2-methylphenyl)-2(1H)-phthalazinyl]-2-prop-2-en-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran; diethyl ether / 6.33 h / 0 °C

2: triethylamine / dichloromethane / 2.33 h / 0 °C

3: 1-ethyl-piperidine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 18 h / 140 °C / Inert atmosphere; sealed tube

With 1-ethyl-piperidine; bis-triphenylphosphine-palladium(II) chloride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 3: Heck reaction;
DOI:10.1016/j.ejmech.2012.05.018

Reference yield:

: 32024-15-0
3,4-dimethoxy-5-iodobenzaldehyde

: 1394153-21-9
(E)-3-{5-[(2,4-diamino-5-pyrimidinyl)methyl]-2,3-dimethoxyphenyl}-1-[1-(2-methylphenyl)-2(1H)-phthalazinyl]-2-prop-2-en-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate / dimethyl sulfoxide / 70 - 72 °C

1.2: 1 h / 72 °C

2.1: aniline hydrochloride / ethanol / 1 h / 78 °C

2.2: 3 h / 78 °C

3.1: 1-ethyl-piperidine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 18 h / 140 °C / Inert atmosphere; sealed tube

With 1-ethyl-piperidine; bis-triphenylphosphine-palladium(II) chloride; sodium methylate; aniline hydrochloride; In ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; 3.1: Heck reaction;
DOI:10.1016/j.ejmech.2012.05.018