5-(3,4-Dimethoxy-5-iodo-benzyl)pyrimidine-2,4-diamine

Base Information

Chemical Name:5-(3,4-Dimethoxy-5-iodo-benzyl)pyrimidine-2,4-diamine
CAS No.:83166-73-8
Molecular Formula:C₁₃H₁₅IN₄O₂
Molecular Weight:386.192
Hs Code.:
DSSTox Substance ID:DTXSID60877199
Nikkaji Number:J1.588.220D
Wikidata:Q82858950
ChEMBL ID:CHEMBL4293337

Synonyms:83166-73-8;SCHEMBL5943361;CHEMBL4293337;DTXSID60877199;ZKFLTJPUAQTMAX-UHFFFAOYSA-N;2,4-NH2PYRIMIDINE,5(3,4MEO-5-I)BENZYL;5-(3,4-dimethoxy-5-iodo-benzyl)pyrimidine-2,4-diamine;5-(3,4-dimethoxy-5-iodobenzyl)-pyrimidine-2,4-diamine;5-(3,4-dimethoxy-5-iodo-benzyl)-pyrimidine-2,4-diamine;2,4-Diamino-5-(3'-iodo-4',5'-dimethoxy-benzyl)pyrimidine;5-[(3-Iodo-4,5-dimethoxyphenyl)methyl]-2,4-pyrimidinediamine

Suppliers and Price of 5-(3,4-Dimethoxy-5-iodo-benzyl)pyrimidine-2,4-diamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(3,4-Dimethoxy-5-iodo-benzyl)pyrimidine-2,4-diamine

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:386.02397
Heavy Atom Count:20
Complexity:310

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C(=CC(=C1)CC2=CN=C(N=C2N)N)I)OC

Technology Process of 5-(3,4-Dimethoxy-5-iodo-benzyl)pyrimidine-2,4-diamine

There total 5 articles about 5-(3,4-Dimethoxy-5-iodo-benzyl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-morpholino-2-(5-iodo-3,4-dimethoxybenzyl)acrylonitrile

: 50-01-1
guanidine hydrochloride

: 83166-73-8
5-(3-iodo-4,5-dimethoxy-benzyl)-pyrimidine-2,4-diamine

Guidance literature:: 3-morpholino-2-(5-iodo-3,4-dimethoxybenzyl)acrylonitrile; With aniline hydrochloride; In ethanol; at 78 ℃; for 1h;

guanidine hydrochloride; With sodium methylate; In ethanol; at 78 ℃; for 3h;
DOI:10.1016/j.ejmech.2012.05.018

Reference yield:

: 32024-15-0
3,4-dimethoxy-5-iodobenzaldehyde

: 83166-73-8
5-(3-iodo-4,5-dimethoxy-benzyl)-pyrimidine-2,4-diamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium methylate / dimethyl sulfoxide / 70 - 72 °C

1.2: 1 h / 72 °C

2.1: aniline hydrochloride / ethanol / 1 h / 78 °C

2.2: 3 h / 78 °C

With sodium methylate; aniline hydrochloride; In ethanol; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2012.05.018

Reference yield:

: 5438-36-8
5-iodovaniline

: 83166-73-8
5-(3-iodo-4,5-dimethoxy-benzyl)-pyrimidine-2,4-diamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 120 °C

2.1: sodium methylate / dimethyl sulfoxide / 70 - 72 °C

2.2: 1 h / 72 °C

3.1: aniline hydrochloride / ethanol / 1 h / 78 °C

3.2: 3 h / 78 °C

With sodium methylate; aniline hydrochloride; potassium carbonate; In ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.05.018