(5R)-5-{(1R,2R)-2-[(tert-butyldiphenylsilanyloxy)methyl]cyclopropyl}-5-(triethylsilanyloxy)pent-1-en-3-ol

Base Information

Chemical Name:(5R)-5-{(1R,2R)-2-[(tert-butyldiphenylsilanyloxy)methyl]cyclopropyl}-5-(triethylsilanyloxy)pent-1-en-3-ol
CAS No.:950588-60-0
Molecular Formula:C₃₁H₄₈O₃Si₂
Molecular Weight:524.891
Hs Code.:

Synonyms:(5R)-5-{(1R,2R)-2-[(tert-butyldiphenylsilanyloxy)methyl]cyclopropyl}-5-(triethylsilanyloxy)pent-1-en-3-ol

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Chemical Property of (5R)-5-{(1R,2R)-2-[(tert-butyldiphenylsilanyloxy)methyl]cyclopropyl}-5-(triethylsilanyloxy)pent-1-en-3-ol

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Technology Process of (5R)-5-{(1R,2R)-2-[(tert-butyldiphenylsilanyloxy)methyl]cyclopropyl}-5-(triethylsilanyloxy)pent-1-en-3-ol

There total 6 articles about (5R)-5-{(1R,2R)-2-[(tert-butyldiphenylsilanyloxy)methyl]cyclopropyl}-5-(triethylsilanyloxy)pent-1-en-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 950588-59-7
(3R)-3-{(1R,2R)-2-[(tert-butyldiphenylsilanyloxy)methyl]cyclopropyl}-3-(triethylsilanyloxy)propionaldehyde

: 1826-67-1
vinyl magnesium bromide

: 950588-60-0
(5R)-5-{(1R,2R)-2-[(tert-butyldiphenylsilanyloxy)methyl]cyclopropyl}-5-(triethylsilanyloxy)pent-1-en-3-ol

Guidance literature:: In tetrahydrofuran; at -78 ℃; for 0.833333h;
DOI:10.1021/ol701564x

Reference yield:

: 950588-55-3
(3R)-6-(tert-butyldiphenylsilanyloxy)-3-hydroxy-1-[(4S)-4-isopropyl-2-thioxothiazolidin-3-yl]hex-4-en-1-one

: 950588-60-0
(5R)-5-{(1R,2R)-2-[(tert-butyldiphenylsilanyloxy)methyl]cyclopropyl}-5-(triethylsilanyloxy)pent-1-en-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 71 percent / imidazole / CH₂Cl₂ / 16 h / 20 °C

2: 97 percent / diethylzinc / CH₂Cl₂; hexane / 3 h / -15 - 20 °C

3: 98 percent / 2,6-lutidine / CH₂Cl₂ / 0.75 h / 0 °C

4: DIBAL-H / tetrahydrofuran / 0.25 h / -78 °C

5: 85 percent / tetrahydrofuran / 0.83 h / -78 °C

With 1H-imidazole; 2,6-dimethylpyridine; diethylzinc; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane; 2: Simmons-Smith cyclopropanation;
DOI:10.1021/ol701564x

Reference yield:

: 950588-57-5
(3R)-3-{(1R,2R)-2-[(tert-butyldiphenylsilanyloxy)methyl]cyclopropyl}-3-hydroxy-N-methoxy-N-methylpropionamide

: 950588-60-0
(5R)-5-{(1R,2R)-2-[(tert-butyldiphenylsilanyloxy)methyl]cyclopropyl}-5-(triethylsilanyloxy)pent-1-en-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / 2,6-lutidine / CH₂Cl₂ / 0.75 h / 0 °C

2: DIBAL-H / tetrahydrofuran / 0.25 h / -78 °C

3: 85 percent / tetrahydrofuran / 0.83 h / -78 °C

With 2,6-dimethylpyridine; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol701564x