N-{4-(2-chloro-4-(4-methoxyphenylsulfanyl)-6-methylphenyl)thiazol-2-yl}isonicotinamide

Base Information

• Chemical Name: N-{4-(2-chloro-4-(4-methoxyphenylsulfanyl)-6-methylphenyl)thiazol-2-yl}isonicotinamide
• CAS No.: 1439935-86-0
• Molecular Formula: C₂₃H₁₈ClN₃O₂S₂
• Molecular Weight: 468
• Mol file: 1439935-86-0.mol

Synonyms:N-{4-(2-chloro-4-(4-methoxyphenylsulfanyl)-6-methylphenyl)thiazol-2-yl}isonicotinamide

Chemical Property of N-{4-(2-chloro-4-(4-methoxyphenylsulfanyl)-6-methylphenyl)thiazol-2-yl}isonicotinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{4-(2-chloro-4-(4-methoxyphenylsulfanyl)-6-methylphenyl)thiazol-2-yl}isonicotinamide

There total 10 articles about N-{4-(2-chloro-4-(4-methoxyphenylsulfanyl)-6-methylphenyl)thiazol-2-yl}isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

4-(2-chloro-4-(4-methoxyphenylsulfanyl)-6-methylphenyl)thiazol-2-ylamine (1439935-89-3) + isonicotinoyl chloride hydrochloride (39178-35-3) → N-{4-(2-chloro-4-(4-methoxyphenylsulfanyl)-6-methylphenyl)thiazol-2-yl}isonicotinamide (1439935-86-0)

Guidance literature:

With dmap;

Reference yield:

1-(2-chloro-4-iodo-6-methylphenyl)ethanone (1334923-28-2) → N-{4-(2-chloro-4-(4-methoxyphenylsulfanyl)-6-methylphenyl)thiazol-2-yl}isonicotinamide (1439935-86-0)

Guidance literature:

Multi-step reaction with 4 steps

1: copper(II) oxide; potassium hydroxide / water; N,N-dimethyl-formamide / 20 h / Reflux

2: tetrabutylammomium bromide / acetonitrile / 0.5 h / 20 °C

3: ethanol / 1 h / Reflux

4: dmap

With dmap; tetrabutylammomium bromide; copper(II) oxide; potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

4-Methoxybenzenethiol (696-63-9) → N-{4-(2-chloro-4-(4-methoxyphenylsulfanyl)-6-methylphenyl)thiazol-2-yl}isonicotinamide (1439935-86-0)

Guidance literature:

Multi-step reaction with 4 steps

1: copper(II) oxide; potassium hydroxide / water; N,N-dimethyl-formamide / 20 h / Reflux

2: tetrabutylammomium bromide / acetonitrile / 0.5 h / 20 °C

3: ethanol / 1 h / Reflux

4: dmap

With dmap; tetrabutylammomium bromide; copper(II) oxide; potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

1-(2-chloro-4-iodo-6-methylphenyl)ethanone

4-Methoxybenzenethiol

1-(2-chloro-4-(4-methoxyphenylsulfanyl)-6-methylphenyl)ethanone

2-bromo-1-(2-chloro-4-(4-methoxyphenylsulfanyl)-6-methylphenyl)ethanone