5-(6-(4-(piperazine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)indolin-2-one

Base Information

Chemical Name:5-(6-(4-(piperazine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)indolin-2-one
CAS No.:1464151-29-8
Molecular Formula:C₂₅H₂₂N₆O₂
Molecular Weight:438.489
Hs Code.:

Synonyms:5-(6-(4-(piperazine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)indolin-2-one

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Chemical Property of 5-(6-(4-(piperazine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)indolin-2-one

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Technology Process of 5-(6-(4-(piperazine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)indolin-2-one

There total 6 articles about 5-(6-(4-(piperazine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)indolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1464155-48-3
tert-butyl 4-(4-(3-(2-oxoindolin-5-yl)imidazo[1,2-b]pyridazin-6-yl)benzoyl)piperazine-1-carboxylate

: 1464151-29-8
5-(6-(4-(piperazine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)indolin-2-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 14047-29-1
4-carboxyphenylboronic acid

: 1464151-29-8
5-(6-(4-(piperazine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)indolin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / water; 1,4-dioxane / 6 h / 20 °C / Inert atmosphere; Reflux

2: N-Bromosuccinimide / acetonitrile / 3 h / 0 °C

3: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

4: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With 4-methyl-morpholine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; HATU; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1084953-09-2
4-(imidazo[1,2-b]pyridazin-6-yl)benzoic acid

: 1464151-29-8
5-(6-(4-(piperazine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)indolin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide / acetonitrile / 3 h / 0 °C

2: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

3: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With 4-methyl-morpholine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; caesium carbonate; HATU; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;