(2S) ethyl 4-hydroxy-2-[4-(4-methoxyphenyl)-5-thioxo-1H-tetrazol-1-yl]butanoate

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Chemical Name:(2S) ethyl 4-hydroxy-2-[4-(4-methoxyphenyl)-5-thioxo-1H-tetrazol-1-yl]butanoate
CAS No.:1260396-10-8
Molecular Formula:C₁₄H₁₈N₄O₄S
Molecular Weight:338.387
Hs Code.:

Synonyms:(2S) ethyl 4-hydroxy-2-[4-(4-methoxyphenyl)-5-thioxo-1H-tetrazol-1-yl]butanoate

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Chemical Property of (2S) ethyl 4-hydroxy-2-[4-(4-methoxyphenyl)-5-thioxo-1H-tetrazol-1-yl]butanoate

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Technology Process of (2S) ethyl 4-hydroxy-2-[4-(4-methoxyphenyl)-5-thioxo-1H-tetrazol-1-yl]butanoate

There total 2 articles about (2S) ethyl 4-hydroxy-2-[4-(4-methoxyphenyl)-5-thioxo-1H-tetrazol-1-yl]butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₄H₁₆N₄O₄S

: 1260396-10-8
(2S) ethyl 4-hydroxy-2-[4-(4-methoxyphenyl)-5-thioxo-1H-tetrazol-1-yl]butanoate

Guidance literature:: With sodium tetrahydroborate; In methanol; toluene; at -78 - -30 ℃; for 1.5h;
DOI:10.1021/ol102892f

Reference yield:

: 2960-66-9
4-oxo-but-2-enoic acid ethyl ester

: 13980-76-2
1-(4-methoxyphenyl)-1H-tetrazole-5-thiol

: 1260396-10-8
(2S) ethyl 4-hydroxy-2-[4-(4-methoxyphenyl)-5-thioxo-1H-tetrazol-1-yl]butanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: (S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; benzoic acid / toluene / 0.5 h / -30 °C

1.2: 92 h / -30 °C

2.1: sodium tetrahydroborate / methanol; toluene / 1.5 h / -78 - -30 °C

With (S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; sodium tetrahydroborate; benzoic acid; In methanol; toluene; 1.1: aza-Michael reaction / 1.2: aza-Michael reaction;
DOI:10.1021/ol102892f