2960-66-9

Basic information

• Product Name: ETHYL TRANS-4-OXO-2-BUTENOATE
• Synonyms: ETHYL TRANS-4-OXO-2-BUTENOATE;Ethyl 3-formylacrylate~Ethyl fumaraldehydate~trans-4-Oxo-2-butenoic acid ethyl ester;ethyl 3-formylacrylate;ethyl fumaraldehydate;Ethyl 4-oxobut-2-enoate;(E)-Ethyl 4-oxobut-2-enoate
• CAS NO: 2960-66-9
• Molecular Formula: C₆H₈O₃
• Molecular Weight: 128.13
• EINECS: 1592732-453-0
• Mol File: 2960-66-9.mol
• Article Data: 23

Chemical Properties

• Melting Point: -9°C
• Boiling Point: 184-188°C
• Flash Point: 68°C
• Appearance: /
• Density: 1,063 g/cm3
• Vapor Pressure: 0.343mmHg at 25°C
• Refractive Index: 1.4550
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Water Solubility: Slightly soluble in water(2.6 g/L at 25°C).
• BRN: 8762336
• CAS DataBase Reference: ETHYL TRANS-4-OXO-2-BUTENOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL TRANS-4-OXO-2-BUTENOATE(2960-66-9)
• EPA Substance Registry System: ETHYL TRANS-4-OXO-2-BUTENOATE(2960-66-9)

Safety Data

• Statements: 25-34-43
• Safety Statements: 23-36/37/39-45-24/25
• RIDADR: 2927
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 2960-66-9(Hazardous Substances Data)

Usage

Uses

Ethyl trans-4-oxo-2-butenoate is an intermediate used to synthesize pharmaceutically active molecules. It is also used in the asymmetric catalytic alkynylation of acetaldehyde, producing attractive synthons with broad applications, such as (+)-Tetrahydropyrenophorol.

Synthesis Reference(s)

The Journal of Organic Chemistry, 49, p. 3421, 1984 DOI: 10.1021/jo00192a047Synthetic Communications, 18, p. 1913, 1988 DOI: 10.1080/00397918808068257Tetrahedron Letters, 31, p. 2145, 1990 DOI: 10.1016/0040-4039(90)80094-3

InChI:InChI=1/C6H8O3/c1-2-9-6(8)4-3-5-7/h3-5H,2H2,1H3/b4-3+

Upstream product

• 623-70-1 ethyl (E)-crotonate 
• 10544-63-5 ethyl crotonate 
• 10080-68-9 (E)-ethyl 4-hydroxybut-2-enoate 
• 1617-18-1 ethyl 3-butenoate 
• 64-17-5 ethanol 
• 2396-84-1 (2E,4E)-ethyl hexa-2,4-dienoate 
• 71666-09-6 ethyl cis-2-ethoxycyclopropanecarboxylate 
• 60212-44-4 ethyl trans-2-ethoxycyclopropanecarboxylate 
• 55531-67-4 ethyl 4,4-diethoxy-2-butenoate 
• 66661-62-9 (E)-4-(Dimethyl-hydrazono)-but-2-enoic acid ethyl ester 
• 40624-13-3 N-3-(1-carbomethoxy)propenylpyridinium bromide 
• 1117-71-1 methyl-4-bromo-2-butenoate 
• 623-43-8 crotonic acid methyl ester 
• 114120-87-5 4,5-Dihydro-isoxazole-5-carboxylic acid ethyl ester 

Downstream Products

• 3025-30-7 ethyl 2,4-decadienoate 
• 130146-83-7 N-(Phenylsulfonyl)-(4-ethoxycarbonyl)-1-aza-1,3-butadiene 
• 130146-83-7 ethyl (E)-4-<(phenylsulfonyl)imino>-2-butenoate 
• 1441-57-2 diethylmuconate 
• 74525-65-8 dodeca-2t,4c,11-trienal 
• 82667-57-0 (2E,4Z)-2,4,10-Dodecatrien-1-al 
• 345619-05-8 (2E,4E)-2,4,10-Dodecatrien-1-al 
• 82667-58-1 (2E,4E)-2,4,11-Dodecatrien-1-al 
• 82667-56-9 (2E,4Z)-2,4,9-Dodecatrien-1-al 
• 345619-07-0 (2E,4E)-2,4,9-Dodecatrien-1-al 
• 3025-30-7 ethyl (2E,4Z)-2,4-decadienoate 
• 7328-34-9 ethyl 2E,4E-decadienoate 
• 140925-20-8 (2S,3S)-3-formyloxirane-2-carboxylic acid ethyl ester 

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