(S)-1-cyclopropyl-3-(4-(6-(2-(dimethylamino)acetyl)-2-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)phenyl)urea

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Chemical Name:(S)-1-cyclopropyl-3-(4-(6-(2-(dimethylamino)acetyl)-2-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)phenyl)urea
CAS No.:1402551-00-1
Molecular Formula:C₂₅H₃₃N₇O₃
Molecular Weight:479.582
Hs Code.:

Synonyms:(S)-1-cyclopropyl-3-(4-(6-(2-(dimethylamino)acetyl)-2-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)phenyl)urea

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Chemical Property of (S)-1-cyclopropyl-3-(4-(6-(2-(dimethylamino)acetyl)-2-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)phenyl)urea

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Technology Process of (S)-1-cyclopropyl-3-(4-(6-(2-(dimethylamino)acetyl)-2-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)phenyl)urea

There total 8 articles about (S)-1-cyclopropyl-3-(4-(6-(2-(dimethylamino)acetyl)-2-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1118-68-9
dimethylaminoacetic acid

: 1402550-81-5
(S)-1-cyclopropyl-3-(4-(2-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)phenyl)urea

: 1402551-00-1
(S)-1-cyclopropyl-3-(4-(6-(2-(dimethylamino)acetyl)-2-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)phenyl)urea

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 171364-83-3
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nitrobenzene

: 1402551-00-1
(S)-1-cyclopropyl-3-(4-(6-(2-(dimethylamino)acetyl)-2-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 7 steps

1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 3 h / 90 °C

2: triethylamine / N,N-dimethyl-formamide / 50 °C

3: hydrogen / palladium 10% on activated carbon / ethanol

4: dichloromethane / 20 °C

5: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

6: ammonia / methanol

7: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; ammonia; hydrogen; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 903129-71-5
tert-butyl 2,4-dichloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylate

: 1402551-00-1
(S)-1-cyclopropyl-3-(4-(6-(2-(dimethylamino)acetyl)-2-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 7 steps

1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 3 h / 90 °C

2: triethylamine / N,N-dimethyl-formamide / 50 °C

3: hydrogen / palladium 10% on activated carbon / ethanol

4: dichloromethane / 20 °C

5: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

6: ammonia / methanol

7: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; ammonia; hydrogen; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;