903129-71-5

Basic information

• Product Name: TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE
• Synonyms: TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE;2,4-Dichloro-6,7-dihydro-6-Boc-5H-pyrrolo[3,4-d]pyrimidine;tert-butyl 2,4-dichloro-5H-pyrrolo[3,4-;6H-Pyrrolo[3,4-d]pyrimidine-6-carboxylicacid, 2,4-dichloro-5,7-dihydro-, 1,1-dimethylethyl ester;tert-Butyl 2,4-dichloro-5H-pyrrolo[3,4-d]pyriMidine-6(7H)-carbox;tert-butyl 2,4-dichloro-5H,6H,7H-pyrrolo[3,4-d]pyriMidine-6-carboxylate;6-Boc-2,4-Dichloro-5,7-dihydropyrrolo[3,4-d]pyriMidine;6-Boc-2,4-dichloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyriMidine
• CAS NO: 903129-71-5
• Molecular Formula: C₁₁H₁₃Cl₂N₃O₂
• Molecular Weight: 290.15
• EINECS: 1533716-785-6
• Product Categories: CHIRAL CHEMICALS;Heterocycle-Pyrimidine series
• Mol File: 903129-71-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 405.8 °C at 760 mmHg
• Flash Point: 199.2 °C
• Appearance: /
• Density: 1.401 g/cm³
• Vapor Pressure: 8.53E-07mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.24±0.20(Predicted)
• CAS DataBase Reference: TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE(903129-71-5)
• EPA Substance Registry System: TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE(903129-71-5)

Safety Data

• Hazardous Substances Data: 903129-71-5(Hazardous Substances Data)

Usage

General Description

TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE is a chemical compound that belongs to the pyrrolopyrimidine family. It is a tert-butyl ester derivative of 2,4-dichloro-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylic acid. TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE is commonly used in the field of medicinal chemistry for the development of pharmaceutical drugs. It has been studied for its potential anti-cancer, anti-inflammatory, and anti-viral properties. The tert-butyl group in the compound has been found to enhance its stability and bioavailability, making it a promising candidate for drug development.

InChI:InChI=1/C11H13Cl2N3O2/c1-11(2,3)18-10(17)16-4-6-7(5-16)14-9(13)15-8(6)12/h4-5H2,1-3H3

Upstream product

• 1190927-74-2 2,4-dichloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1027-35-6 1-Benzyl-4-oxo-pyrrolidine-3-carboxylic Acid Ethyl Ester 
• 795-18-6 3-(benzyl-ethoxy-carbonylmethyl-amino)-propionic acid ethyl ester 
• 3783-61-7 diethyl 2-azabutane-1,4-dicarboxylate 
• 785775-01-1 2,4-dichloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine 
• 779323-58-9 6-benzyl-2,4-dichloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin 

Downstream Products

• 1374675-84-9 2-Chloro-4-{(S)-3-[2-chloro-4-(2,2,2-trifluoro-ethoxy)-benzenesulfonyl]-pyrrolidin-1-yl}-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine 
• 1374675-85-0 2-Chloro-4-{(S)-3-[2-chloro-4-(2,2,2-trifluoro-ethoxy)-benzenesulfonyl]-pyrrolidin-1-yl}-6-(2,2,2-trifluoro-ethyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine 
• 1374675-83-8 2-Chloro-4-{(S)-3-[2-chloro-4-(2,2,2-trifluoro-ethoxy)-benzenesulfonyl]-pyrrolidin-1-yl}-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid tert-butyl ester 
• 1542711-39-6 C₁₈H₂₁ClN₄O₂ 
• 1542711-40-9 C₂₇H₂₉N₅O₂ 
• 1542709-08-9 N-benzyl-2-(2-methyl-1H-indol-1-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-amine 
• 1190927-74-2 2,4-dichloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine hydrochloride 

Relevant articles and documents

INHIBITORS OF KRAS G12C

Disclosed herein are compounds that inhibit KRas G12C, pharmaceutical compositions, methods of preparation and uses thereof.