903129-71-5

Usage

Uses

Used in Pharmaceutical Development:
TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE is used as a key intermediate in the synthesis of pharmaceutical drugs for its potential anti-cancer, anti-inflammatory, and anti-viral properties.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE is used as a research compound to explore its therapeutic potential and optimize its properties for drug development.
Used in Drug Stability and Bioavailability Enhancement:
The tert-butyl group in TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE is used to improve the stability and bioavailability of the compound, making it a more effective candidate for drug development.
Used in Cancer Treatment:
TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE is used as a potential anti-cancer agent in oncology research, targeting various types of cancer through its therapeutic properties.
Used in Inflammation Management:
In the field of inflammation management, TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE is used as a potential anti-inflammatory agent to study its effects on reducing inflammation and related conditions.
Used in Antiviral Therapy:
TERT-BUTYL 2,4-DICHLORO-5H-PYRROLO[3,4-D]PYRIMIDINE-6(7H)-CARBOXYLATE is used as a potential anti-viral agent in virology research, exploring its ability to inhibit viral replication and treat viral infections.

InChI:InChI=1/C11H13Cl2N3O2/c1-11(2,3)18-10(17)16-4-6-7(5-16)14-9(13)15-8(6)12/h4-5H2,1-3H3

Upstream product

• 779323-58-9 6-benzyl-2,4-dichloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin 
• 785775-01-1 2,4-dichloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 3783-61-7 diethyl 2-azabutane-1,4-dicarboxylate 
• 795-18-6 3-(benzyl-ethoxy-carbonylmethyl-amino)-propionic acid ethyl ester 
• 1027-35-6 1-Benzyl-4-oxo-pyrrolidine-3-carboxylic Acid Ethyl Ester 
• 1190927-74-2 2,4-dichloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine hydrochloride 

Downstream Products

• 1207365-96-5 tert-butyl 2-(4-(3-ethylureido)phenyl)-4-morpholino-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate 
• 1207357-39-8 1-ethyl-3-(4-(4-morpholino-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea 
• 1207357-41-2 1-ethyl-3-(4-(4-morpholino-6-(pyrimidin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea 
• 1211581-47-3 tert-butyl 2-chloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylate 
• 1190927-74-2 2,4-dichloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine hydrochloride 
• 1402551-46-5 (S)-tert-butyl 2-(3-methylmorpholino)-4-(4-nitrophenyl)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate 
• 1402551-13-6 1-cyclopropyl-3-(4-(2-((S)-3-methylmorpholino)-6-(tetrahydrofuran-2-carbonyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)phenyl)urea 
• 1402551-04-5 (S)-1-(4-(2-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)phenyl)-3-(pyridin-4-yl)urea 
• 1402551-00-1 (S)-1-cyclopropyl-3-(4-(6-(2-(dimethylamino)acetyl)-2-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)phenyl)urea 
• 1402550-97-3 (S)-4-(4-(3-cyclopropylureido)phenyl)-N-ethyl-2-(3-methylmorpholino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide 
• 1402551-62-5 tert-butyl 4-(4-((S)-3-methylmorpholine-4-carboxamido)phenyl)-2-((S)-3-methylmorpholino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate 
• 1402550-95-1 (S)-1-cyclopropyl-3-(4-(2-(3-methylmorpholino)-6-(methylsulfonyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)phenyl)urea 
• 1402550-92-8 (S)-1-(4-(6-acetyl-2-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)phenyl)-3-cyclopropylurea 
• 1402550-91-7 (S)-1-cyclopropyl-3-(4-(6-methyl-2-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)phenyl)urea 

Relevant academic research and scientific papers

INHIBITORS OF KRAS G12C

Disclosed herein are compounds that inhibit KRas G12C, pharmaceutical compositions, methods of preparation and uses thereof.

Pyrrolidine [3,4-d] pyrimidine derivatives, preparation method and its application

The invention discloses a pyrrolidine[3,4-d]pyrimidine derivative and a preparation method and an application thereof. The pyrrolidine[3,4-d]pyrimidine derivative is an inhibitor of a type I insulin-like growth factor receptor (IGF-1R), and has a good IGF-1R inhibiting function and a good cancer cell proliferation inhibiting function, so that the pyrrolidine[3,4-d]pyrimidine derivative can be taken as a therapeutic agent for treating tumors and relevant diseases.