4-methyl -N-<<1-<<<<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-2-oxoethyl>amino>carbonyl>amino>cyclohexyl>carbonyl>-L-aspartate

Base Information

Chemical Name:4-methyl -N-<<1-<<<<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-2-oxoethyl>amino>carbonyl>amino>cyclohexyl>carbonyl>-L-aspartate
CAS No.:144876-88-0
Molecular Formula:C₃₂H₄₀N₆O₇
Molecular Weight:620.706
Hs Code.:

4-methyl <R-(R*,R*)>-N-<<1-<<<<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-2-oxoethyl>amino>carbonyl>amino>cyclohexyl>carbonyl>-L-aspartate

Synonyms:4-methyl -N-<<1-<<<<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-2-oxoethyl>amino>carbonyl>amino>cyclohexyl>carbonyl>-L-aspartate

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Chemical Property of 4-methyl -N-<<1-<<<<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-2-oxoethyl>amino>carbonyl>amino>cyclohexyl>carbonyl>-L-aspartate

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Technology Process of 4-methyl -N-<<1-<<<<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-2-oxoethyl>amino>carbonyl>amino>cyclohexyl>carbonyl>-L-aspartate

There total 12 articles about 4-methyl -N-<<1-<<<<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-2-oxoethyl>amino>carbonyl>amino>cyclohexyl>carbonyl>-L-aspartate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 144876-84-6
4-methyl-1-(phenylmethyl) -N-<<1-<<<<1-(1H-indol-3-ylmethyl)-2-oxo-2-<<2-phenyl-2-<<(phenylmethoxy)carbonyl>amino>ethyl>amino>ethyl>amino>carbonyl>amino>cyclohexyl>carbonyl>-L-aspartate

: 144876-88-0
4-methyl -N-<<1-<<<<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-2-oxoethyl>amino>carbonyl>amino>cyclohexyl>carbonyl>-L-aspartate

Guidance literature:: With hydrogen; palladium dihydroxide; In Petroleum ether; at 25 ℃; for 12h; under 2327.2 Torr;
DOI:10.1016/S0040-4020(01)86596-0

Reference yield:

: 2756-85-6
1-aminocyclohexane carboxylic acid

: 144876-88-0
4-methyl -N-<<1-<<<<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-2-oxoethyl>amino>carbonyl>amino>cyclohexyl>carbonyl>-L-aspartate

Guidance literature:: Multi-step reaction with 8 steps

1: 52 percent

2: 68 percent / dicyclohexylcarbodiimide, 4-dimethylaminopyridine / acetonitrile; dimethylformamide / 24 h / Ambient temperature

3: 99 percent / H₂ / 20percent Pd(OH)2/C / propan-2-ol / 17 h / 25 °C / 2327.2 Torr

4: 96 percent / NEt₃ / tetrahydrofuran / 25 °C

5: 81 percent / toluene; tetrahydrofuran / 16 h / 80 - 100 °C

6: 95 percent / TFA / CH₂Cl₂ / 17 h / 25 °C

7: 80 percent / BOP, i-Pr₂NEt / dimethylformamide / 12 h / 25 °C

8: 1.1 g / H₂ / 20percent Pd(OH)2/C / petroleum ether / 12 h / 25 °C / 2327.2 Torr

With dmap; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile; Petroleum ether;
DOI:10.1016/S0040-4020(01)86596-0

Reference yield:

: 17191-43-4
1-{[(benzyloxy)carbonyl]amino}cyclohexanecarboxylic acid

: 144876-88-0
4-methyl -N-<<1-<<<<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-2-oxoethyl>amino>carbonyl>amino>cyclohexyl>carbonyl>-L-aspartate

Guidance literature:: Multi-step reaction with 7 steps

1: 68 percent / dicyclohexylcarbodiimide, 4-dimethylaminopyridine / acetonitrile; dimethylformamide / 24 h / Ambient temperature

2: 99 percent / H₂ / 20percent Pd(OH)2/C / propan-2-ol / 17 h / 25 °C / 2327.2 Torr

3: 96 percent / NEt₃ / tetrahydrofuran / 25 °C

4: 81 percent / toluene; tetrahydrofuran / 16 h / 80 - 100 °C

5: 95 percent / TFA / CH₂Cl₂ / 17 h / 25 °C

6: 80 percent / BOP, i-Pr₂NEt / dimethylformamide / 12 h / 25 °C

7: 1.1 g / H₂ / 20percent Pd(OH)2/C / petroleum ether / 12 h / 25 °C / 2327.2 Torr

With dmap; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile; Petroleum ether;
DOI:10.1016/S0040-4020(01)86596-0