1-(Cbz-amino)cyclohexanecarboxylic acid

Base Information

• Chemical Name: 1-(Cbz-amino)cyclohexanecarboxylic acid
• CAS No.: 17191-43-4
• Molecular Formula: C15H19NO4
• Molecular Weight: 277.32
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID60463495
• Mol file: 17191-43-4.mol

Synonyms:17191-43-4;1-(CBZ-AMINO)CYCLOHEXANECARBOXYLIC ACID;1-(((Benzyloxy)carbonyl)amino)cyclohexanecarboxylic acid;1-(phenylmethoxycarbonylamino)cyclohexane-1-carboxylic acid;MFCD02094521;1-{[(benzyloxy)carbonyl]amino}cyclohexanecarboxylic acid;1-{[(Benzyloxy)carbonyl]amino}cyclohexane-1-carboxylic acid;Z-NH(1)cHex-OH;1-(((Benzyloxy)carbonyl)amino)cyclohexane-1-carboxylic acid;1-(Cbz-amino)cyclohexanecarboxylicAcid;Cyclohexanecarboxylic acid, 1-[[(phenylmethoxy)carbonyl]amino]-;1-Benzyloxycarbonylaminocyclohexanecarboxylic acid;SCHEMBL1839379;DTXSID60463495;UZRXLKFQBCCVJH-UHFFFAOYSA-N;1-(BENZYLOXYCARBONYLAMINO)CYCLOHEXANE-1-CARBOXYLIC ACID;AKOS000168143;AB91124;CS-11025;SY003145;CS-0059144;FT-0719584;EN300-84291;A881902;1-benzyloxycarbonylaminocyclohexane-1-carboxylic acid;N-Benzyloxycarbonyl-1-amino-cyclohexanecarboxylic acid;1-(CbZ-amino)cyclohexanecarboxylic acid (CbZ-Ac6c-OH);Cyclohexa;LogP;1-(Cbz-amino)cyclohexanecarboxylic Acid;1-[[(phenylmethoxy)carbonyl]amino]cyclohexanecarboxylic acid

Chemical Property of 1-(Cbz-amino)cyclohexanecarboxylic acid

Chemical Property:

• Vapor Pressure: 5.62E-10mmHg at 25°C
• Boiling Point: 478.8°C at 760 mmHg
• Flash Point: 243.4°C
• PSA: 75.63000
• Density: 1.23g/cm³
• LogP: 3.09120
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 277.13140809
• Heavy Atom Count: 20
• Complexity: 344

Purity/Quality:

97% ^*data from raw suppliers

1-{(Benzyloxy)carbonylamino}cyclohexanecarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)(C(=O)O)NC(=O)OCC2=CC=CC=C2

Technology Process of 1-(Cbz-amino)cyclohexanecarboxylic acid

There total 8 articles about 1-(Cbz-amino)cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-aminocyclohexane carboxylic acid (2756-85-6) + benzyl chloroformate (501-53-1,94274-21-2) → 1-{[(benzyloxy)carbonyl]amino}cyclohexanecarboxylic acid (17191-43-4)

Guidance literature:

With sodium hydroxide; In water; for 2h;

Reference yield: 67.0%

benzyl (1-vinylcyclohexyl)carbamate → 1-{[(benzyloxy)carbonyl]amino}cyclohexanecarboxylic acid (17191-43-4)

Guidance literature:

benzyl (1-vinylcyclohexyl)carbamate; With ozone; In dichloromethane; at -78 ℃;

With sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; In water; tert-butyl alcohol;

DOI:10.1021/acs.joc.5b02628

Reference yield: 67.0%

→ 1-{[(benzyloxy)carbonyl]amino}cyclohexanecarboxylic acid (17191-43-4)

Guidance literature:

upstream raw materials:

1-aminocyclohexane carboxylic acid

benzyl chloroformate

ethyl cyclohexylideneacetate

cyclohexanone

Downstream raw materials:

(R)-1-{(S)-2-[(1-Benzyloxycarbonylamino-cyclohexanecarbonyl)-amino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid tert-butyl ester

1-Amino-cyclohexanecarboxylic acid 2-trimethylsilanyl-ethyl ester

2-(trimethylsilyl)ethyl-1-isocyanato-1-cyclohexane carboxylate

<10R-(10α,14β,17α)>-10-(1H-indol-3-ylmethyl)-8,11,16,19-tetraoxo-14-phenyl-7,9,12,15,18-pentaazaspiro<5,13>nonadecane-17-acetic acid