2-[2-Oxo-6-phenyl-3-(3-pyridin-3-ylmethyl-ureido)-2H-pyridin-1-yl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-acetamide

Base Information

• Chemical Name: 2-[2-Oxo-6-phenyl-3-(3-pyridin-3-ylmethyl-ureido)-2H-pyridin-1-yl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-acetamide
• CAS No.: 147268-24-4
• Molecular Formula: C₂₆H₂₆F₃N₅O₄
• Molecular Weight: 529.519
• Mol file: 147268-24-4.mol

Synonyms:2-[2-Oxo-6-phenyl-3-(3-pyridin-3-ylmethyl-ureido)-2H-pyridin-1-yl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-acetamide

Chemical Property of 2-[2-Oxo-6-phenyl-3-(3-pyridin-3-ylmethyl-ureido)-2H-pyridin-1-yl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-Oxo-6-phenyl-3-(3-pyridin-3-ylmethyl-ureido)-2H-pyridin-1-yl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-acetamide

There total 6 articles about 2-[2-Oxo-6-phenyl-3-(3-pyridin-3-ylmethyl-ureido)-2H-pyridin-1-yl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide (147269-02-1) → 2-[2-Oxo-6-phenyl-3-(3-pyridin-3-ylmethyl-ureido)-2H-pyridin-1-yl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-acetamide (147268-24-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 95 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 5 h / 760 Torr

2: Et₃N / CH₂Cl₂ / 0.75 h / 0 °C

3: CH₂Cl₂ / 0 - 20 °C

4: tetrabutylammonium fluoride / tetrahydrofuran / 4.5 h

5: Cl₂CHCOOH, WSCDI / toluene; dimethylsulfoxide

With dichloro-acetic acid; tetrabutyl ammonium fluoride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene;

DOI:10.1021/jm00046a016

Reference yield:

2-[2-Oxo-6-phenyl-3-(3-pyridin-3-ylmethyl-ureido)-2H-pyridin-1-yl]-N-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propyl)-acetamide (147284-11-5) → 2-[2-Oxo-6-phenyl-3-(3-pyridin-3-ylmethyl-ureido)-2H-pyridin-1-yl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-acetamide (147268-24-4)

Guidance literature:

With dichloro-acetic acid; In dimethyl sulfoxide; toluene;

DOI:10.1021/jm00046a016

Reference yield:

3-Aminomethylpyridine (3731-52-0) → 2-[2-Oxo-6-phenyl-3-(3-pyridin-3-ylmethyl-ureido)-2H-pyridin-1-yl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-acetamide (147268-24-4)

Guidance literature:

Multi-step reaction with 3 steps

1: CH₂Cl₂ / 0 - 20 °C

2: tetrabutylammonium fluoride / tetrahydrofuran / 4.5 h

3: Cl₂CHCOOH, WSCDI / toluene; dimethylsulfoxide

With dichloro-acetic acid; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene;

DOI:10.1021/jm00046a016

upstream raw materials:

2-[2-Oxo-6-phenyl-3-(3-pyridin-3-ylmethyl-ureido)-2H-pyridin-1-yl]-N-(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propyl)-acetamide

3-Aminomethylpyridine

2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide

2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide