1-(2-{4-[2,8-bis(tert-butyldimethylsilyloxy)-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalene-5-yl]phenoxy}ethyl)piperidine

Base Information

Chemical Name:1-(2-{4-[2,8-bis(tert-butyldimethylsilyloxy)-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalene-5-yl]phenoxy}ethyl)piperidine
CAS No.:554430-45-4
Molecular Formula:C₄₂H₅₉NO₅Si₂
Molecular Weight:714.105
Hs Code.:

Synonyms:1-(2-{4-[2,8-bis(tert-butyldimethylsilyloxy)-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalene-5-yl]phenoxy}ethyl)piperidine

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Chemical Property of 1-(2-{4-[2,8-bis(tert-butyldimethylsilyloxy)-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalene-5-yl]phenoxy}ethyl)piperidine

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 1-(2-{4-[2,8-bis(tert-butyldimethylsilyloxy)-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalene-5-yl]phenoxy}ethyl)piperidine

There total 12 articles about 1-(2-{4-[2,8-bis(tert-butyldimethylsilyloxy)-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalene-5-yl]phenoxy}ethyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 554430-44-3
2,8-bis(tert-butyldimethylsilyloxy)-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalene-5-ol

: 103808-68-0
4-[2-(piperidin-1-yl)-ethoxy]-iodobenzene

: 554430-45-4
1-(2-{4-[2,8-bis(tert-butyldimethylsilyloxy)-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalene-5-yl]phenoxy}ethyl)piperidine

Guidance literature:: With n-butyllithium; ammonium chloride; sodium hydrogencarbonate; In tetrahydrofuran; pentane;

Reference yield:

: 946534-26-5
(Z)-2-(5-(hydroxy(4-(2-(piperidin-1-yl)ethoxy)phenyl)methyl)(8-tert-butyldimethylsilyloxy-2,3-dihydrobenzo[b]oxepin-4-yl)-5-(tert-butyldimethylsilyloxy))phenol

: 554430-45-4
1-(2-{4-[2,8-bis(tert-butyldimethylsilyloxy)-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalene-5-yl]phenoxy}ethyl)piperidine

Guidance literature:: With hydrogenchloride; In water; toluene; at 0 ℃; for 1h;
DOI:10.1021/jm900146e

Reference yield:

: 554430-44-3
2,8-bis(tert-butyldimethylsilyloxy)-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalene-5-ol

: 554430-45-4
1-(2-{4-[2,8-bis(tert-butyldimethylsilyloxy)-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalene-5-yl]phenoxy}ethyl)piperidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1.33 h / -76 - -73 °C / Inert atmosphere

1.2: 2.33 h / -73 °C / Inert atmosphere

2.1: hydrogenchloride / water / 0.75 h / 10 - 20 °C / Inert atmosphere

With hydrogenchloride; n-butyllithium; In tetrahydrofuran; hexane; water;
DOI:10.1021/op700061x