(Z)-2-(5-(hydroxy(4-(2-(piperidin-1-yl)ethoxy)phenyl)methyl)(8-tert-butyldimethylsilyloxy-2,3-dihydrobenzo[b]oxepin-4-yl)-5-(tert-butyldimethylsilyloxy))phenol

Base Information

Chemical Name:(Z)-2-(5-(hydroxy(4-(2-(piperidin-1-yl)ethoxy)phenyl)methyl)(8-tert-butyldimethylsilyloxy-2,3-dihydrobenzo[b]oxepin-4-yl)-5-(tert-butyldimethylsilyloxy))phenol
CAS No.:946534-26-5
Molecular Formula:C₄₂H₆₁NO₆Si₂
Molecular Weight:732.12
Hs Code.:

(Z)-2-(5-(hydroxy(4-(2-(piperidin-1-yl)ethoxy)phenyl)methyl)(8-tert-butyldimethylsilyloxy-2,3-dihydrobenzo[b]oxepin-4-yl)-5-(tert-butyldimethylsilyloxy))phenol

Synonyms:(Z)-2-(5-(hydroxy(4-(2-(piperidin-1-yl)ethoxy)phenyl)methyl)(8-tert-butyldimethylsilyloxy-2,3-dihydrobenzo[b]oxepin-4-yl)-5-(tert-butyldimethylsilyloxy))phenol

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Chemical Property of (Z)-2-(5-(hydroxy(4-(2-(piperidin-1-yl)ethoxy)phenyl)methyl)(8-tert-butyldimethylsilyloxy-2,3-dihydrobenzo[b]oxepin-4-yl)-5-(tert-butyldimethylsilyloxy))phenol

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Technology Process of (Z)-2-(5-(hydroxy(4-(2-(piperidin-1-yl)ethoxy)phenyl)methyl)(8-tert-butyldimethylsilyloxy-2,3-dihydrobenzo[b]oxepin-4-yl)-5-(tert-butyldimethylsilyloxy))phenol

There total 9 articles about (Z)-2-(5-(hydroxy(4-(2-(piperidin-1-yl)ethoxy)phenyl)methyl)(8-tert-butyldimethylsilyloxy-2,3-dihydrobenzo[b]oxepin-4-yl)-5-(tert-butyldimethylsilyloxy))phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 554430-44-3
2,8-bis(tert-butyldimethylsilyloxy)-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalene-5-ol

: 103808-68-0
4-[2-(piperidin-1-yl)-ethoxy]-iodobenzene

: 946534-26-5
(Z)-2-(5-(hydroxy(4-(2-(piperidin-1-yl)ethoxy)phenyl)methyl)(8-tert-butyldimethylsilyloxy-2,3-dihydrobenzo[b]oxepin-4-yl)-5-(tert-butyldimethylsilyloxy))phenol

Guidance literature:: 4-[2-(piperidin-1-yl)-ethoxy]-iodobenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

2,8-bis(tert-butyldimethylsilyloxy)-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalene-5-ol; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;
DOI:10.1021/jm900146e

Reference yield:

: 554430-44-3
2,8-bis(tert-butyldimethylsilyloxy)-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalene-5-ol

: 836-58-8
1-[2-(4-bromophenoxy)ethyl]piperidine

: 946534-26-5
(Z)-2-(5-(hydroxy(4-(2-(piperidin-1-yl)ethoxy)phenyl)methyl)(8-tert-butyldimethylsilyloxy-2,3-dihydrobenzo[b]oxepin-4-yl)-5-(tert-butyldimethylsilyloxy))phenol

: 74-41-9
1-Piperidino-2-phenoxyethane

Guidance literature:: 1-[2-(4-bromophenoxy)ethyl]piperidine; With n-butyllithium; In tetrahydrofuran; hexane; at -76 - -73 ℃; for 1.33333h; Inert atmosphere;

2,8-bis(tert-butyldimethylsilyloxy)-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthalene-5-ol; In tetrahydrofuran; hexane; at -73 ℃; for 2.33333h; Inert atmosphere;
DOI:10.1021/op700061x

Reference yield:

: 6496-89-5
2,4-dimethoxyphenylacetic acid

: 946534-26-5
(Z)-2-(5-(hydroxy(4-(2-(piperidin-1-yl)ethoxy)phenyl)methyl)(8-tert-butyldimethylsilyloxy-2,3-dihydrobenzo[b]oxepin-4-yl)-5-(tert-butyldimethylsilyloxy))phenol

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine; acetic anhydride / o-xylene / 0.5 h / 20 °C

1.2: 50 h / 150 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -20 °C

2.2: 1.17 h / -20 - 0 °C

3.1: boron tribromide / dichloromethane / 7.33 h / 20 - 34 °C / Inert atmosphere

4.1: ethanol / 18.17 h / 0 - 26 °C / Inert atmosphere

5.1: di-isopropyl azodicarboxylate / tetrahydrofuran / 1.08 h / -5 - 0 °C

5.2: 18.5 h / 20 °C

6.1: triethylamine / dichloromethane / 0.17 h / 20 °C

6.2: 21 h / 20 - 30 °C

7.1: diisobutylaluminium hydride / dichloromethane / 2.25 h / -20 °C / Inert atmosphere

8.1: n-butyllithium / tetrahydrofuran; hexane / 1.33 h / -76 - -73 °C / Inert atmosphere

8.2: 2.33 h / -73 °C / Inert atmosphere

With n-butyllithium; ethanol; di-isopropyl azodicarboxylate; acetic anhydride; boron tribromide; diisobutylaluminium hydride; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane; o-xylene;
DOI:10.1021/op700061x