Chemical Property of Perindoprilat
Chemical Property:
- Vapor Pressure:2.17E-14mmHg at 25°C
- Melting Point:153-155掳C
- Boiling Point:568.1 °C at 760 mmHg
- PKA:2.27±0.20(Predicted)
- Flash Point:297.4 °C
- PSA：106.94000
- Density:1.222 g/cm3
- LogP:1.79090
- Storage Temp.:-20°C Freezer
- Solubility.:DMSO (Slightly), Methanol (Slightly)
- XLogP3:0.2
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:7
- Exact Mass:340.19982200
- Heavy Atom Count:24
- Complexity:495
- Purity/Quality:
-
99%, *data from raw suppliers
Perindoprilat(MixtureofDiastereomers) *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CCCC(C(=O)O)NC(C)C(=O)N1C2CCCCC2CC1C(=O)O
- Isomeric SMILES:CCC[C@@H](C(=O)O)N[C@@H](C)C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)O
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Uses
Perindoprilat is the active metabolite of perindopril, an inhibitor of angiotensin converting enzyme (ACE) that has efficacy against hypertension. Perindoprilat specifically and competitively inhibits ACE in vitro with IC50 values ranging between 1.5 and 3.2 nM. Elimination of perindoprilat is decreased in the elderly and in patients with heart or renal failure.[Cayman Chemical] Perindoprilat is an angiotensin-converting enzyme (ACE) inhibitor and antihypertensive.
