Perindopril erbumine

Base Information

• Chemical Name: Perindopril erbumine
• CAS No.: 107133-36-8
• Molecular Formula: C19H32N2O5^.C4H11N
• Molecular Weight: 441.612
• Hs Code.: 2933999552
• European Community (EC) Number: 600-798-6
• NSC Number: 758929
• UNII: 1964X464OJ
• DSSTox Substance ID: DTXSID1044198
• Wikidata: Q27107642
• NCI Thesaurus Code: C47666
• RXCUI: 72260
• ChEMBL ID: CHEMBL1200343
• Mol file: 107133-36-8.mol

Synonyms:Erbumine, Perindopril;Perindopril;Perindopril Erbumine;Perstarium;Pirindopril;S 9490;S 9490 3;S 9490-3;S 94903;S-9490;S9490

Chemical Property of Perindopril erbumine

Chemical Property:

• Appearance/Colour: white solid
• Melting Point: 126-128 °C
• Boiling Point: 537.4 °C at 760 mmHg
• Flash Point: 278.8 °C
• PSA: 121.96000
• Density: 1.15 g/cm³
• LogP: 3.71330
• Storage Temp.: -20°C Freezer
• Solubility.: H2O: soluble10mg/mL, clear
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 9
• Exact Mass: 441.32027148
• Heavy Atom Count: 31
• Complexity: 549

Purity/Quality:

99%, ^*data from raw suppliers

Perindopril erbumine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC(C(=O)OCC)NC(C)C(=O)N1C2CCCCC2CC1C(=O)O.CC(C)(C)N
• Isomeric SMILES: CCC[C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)O.CC(C)(C)N
• Recent ClinicalTrials: Evaluation of the Clinical Efficacy and Safety of Amlodipine 5mg/ Bisoprolol Fumarate 5mg /Perindopril Arginine 5mg Fixed-dose Combination in Capsule and Free Monotherapy at the Same Dose in Patients With Uncontrolled Essential Hypertension.
• Recent EU Clinical Trials: A Multi-Centred, Open Label, Randomised Study Assessing the Cardiovascular Outcomes Following Treatment of White Coat Hypertension with Established Anti-Hypertensive Drugs versus Standard of Care in the Very Elderly - Feasibility Study
• Uses: An angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive. antibacterial
• Therapeutic Function: Antihypertensive

Technology Process of Perindopril erbumine

There total 36 articles about Perindopril erbumine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Perindopril (82834-16-0,145513-33-3,82978-68-5,99149-83-4) → perindopril tert-butylamine (107133-36-8)

Guidance literature:

With tert-butylamine; In ethyl acetate; acetonitrile; Heating / reflux;

Reference yield: 95.0%

Perindopril (82834-16-0,145513-33-3,82978-68-5,99149-83-4) + tert-butylamine (75-64-9) → perindopril tert-butylamine (107133-36-8)

Guidance literature:

In ethyl acetate; Heating / reflux;

Reference yield: 90.0%

tert-butylamine (75-64-9) → perindopril tert-butylamine (107133-36-8)

Guidance literature:

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid; With tert-butylimino-tri(pyrrolidino)phosphorane; In acetonitrile;

N-[1(S)-(ethoxycarbonyl)butyl]-L-alanine ester of acetonoxime; In acetonitrile; at 50 ℃; for 0.5h;

tert-butylamine; In dichloromethane; at 0 - 10 ℃; for 0.5h; Product distribution / selectivity;

upstream raw materials:

Perindopril

tert-butylamine

octahydro-1H-indole-2-carboxylic acid

(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

Downstream raw materials:

perindopril L-arginine

(2S,3aS,7aS)-1-[(S)-N-[(S)-1-carboxy-butyl]alanyl]hexahydro-2-indolinecarboxylic acid 1-ethyl ester para-toluenesulfonate

ethyl (2S)-2-[(3S,5aS,9aS,10aS)-3-methyl-1,4-dioxo-5a,6,7,8,9,9a,10,10a-octahydro-3H-pyrazino[1,2-a]indol-2-yl]pentanoate

perindoprilat

Refernces

• 1、 -. "PROCESS FOR THE PREPARATION OF PERINDOPRIL ERBUMINE SALT AND NOVEL POLYMORPH (S) THEREOF". Page/Page column 12; 12-13. . Retrieved 2008/12/07.
• 2、 -. "NOVEL METHOD FOR THE SYNTHESIS OF PERINDOPRIL AND THE PHARMACEUTICALLY-ACCEPTABLE SALTS THEREOF". Page/Page column 2. . Retrieved 2008/06/13.