(1R,2S,3S,5S)-3-(3-Amino-4-iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester

Base Information

Chemical Name:(1R,2S,3S,5S)-3-(3-Amino-4-iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester
CAS No.:199591-09-8
Molecular Formula:C₁₆H₂₁IN₂O₂
Molecular Weight:400.259
Hs Code.:

Synonyms:(1R,2S,3S,5S)-3-(3-Amino-4-iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2S,3S,5S)-3-(3-Amino-4-iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester

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Technology Process of (1R,2S,3S,5S)-3-(3-Amino-4-iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester

There total 2 articles about (1R,2S,3S,5S)-3-(3-Amino-4-iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 199591-07-6
(1R,2S,3S,5S)-3-(4-Iodo-3-nitro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester

: 199591-09-8
(1R,2S,3S,5S)-3-(3-Amino-4-iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester

Guidance literature:: With iron; acetic acid; In ethanol; water; for 20h; Heating;
DOI:10.1002/jhet.5570340541

Reference yield:

: 135416-43-2,133647-95-7
(1R,2S,3S,5S)-3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester

: 199591-09-8
(1R,2S,3S,5S)-3-(3-Amino-4-iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 54 percent / NO₂BF₄ / acetonitrile / 1.) from 0 deg C to 2 deg C, 7 h, 2.) -5 deg C, 12 h

2: 66 percent / Fe, AcOH / ethanol; H₂O / 20 h / Heating

With nitronium tetrafluoborate; iron; acetic acid; In ethanol; water; acetonitrile;
DOI:10.1002/jhet.5570340541

Reference yield:

: 199591-09-8
(1R,2S,3S,5S)-3-(3-Amino-4-iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester

: (1R,2S,3S,5S)-3-(3-Hydroxy-4-iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester

Guidance literature:: With sodium hydrogen sulfate; tetrafluoroboric acid; sodium nitrite; Yield given. Multistep reaction; 1.) THF, 0 deg C, 2.5 h, 2.) THF, 70 deg C, 2 h;
DOI:10.1002/jhet.5570340541