(1R,2S,3S,5S)-3-(4-Iodo-3-nitro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester

Base Information

• Chemical Name: (1R,2S,3S,5S)-3-(4-Iodo-3-nitro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester
• CAS No.: 199591-07-6
• Molecular Formula: C₁₆H₁₉IN₂O₄
• Molecular Weight: 430.242

Synonyms:(1R,2S,3S,5S)-3-(4-Iodo-3-nitro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester

Chemical Property of (1R,2S,3S,5S)-3-(4-Iodo-3-nitro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (1R,2S,3S,5S)-3-(4-Iodo-3-nitro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester

There total 1 articles about (1R,2S,3S,5S)-3-(4-Iodo-3-nitro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

(1R,2S,3S,5S)-3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester (135416-43-2,133647-95-7) → (1R,2S,3S,5S)-3-(4-Iodo-2-nitro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester + (1R,2S,3S,5S)-3-(4-Iodo-3-nitro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester (199591-07-6)

Guidance literature:

With nitronium tetrafluoborate; In acetonitrile; 1.) from 0 deg C to 2 deg C, 7 h, 2.) -5 deg C, 12 h;

DOI:10.1002/jhet.5570340541

Reference yield: 66.0%

(1R,2S,3S,5S)-3-(4-Iodo-3-nitro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester (199591-07-6) → (1R,2S,3S,5S)-3-(3-Amino-4-iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester (199591-09-8)

Guidance literature:

With iron; acetic acid; In ethanol; water; for 20h; Heating;

DOI:10.1002/jhet.5570340541

Reference yield:

(1R,2S,3S,5S)-3-(4-Iodo-3-nitro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester (199591-07-6) → (1R,2S,3S,5S)-3-(3-Hydroxy-4-iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / Fe, AcOH / ethanol; H₂O / 20 h / Heating

2: 1.) aq. HBF₄, aq. NaNO₂, 2.) aq. NaHSO₄ / 1.) THF, 0 deg C, 2.5 h, 2.) THF, 70 deg C, 2 h

With sodium hydrogen sulfate; tetrafluoroboric acid; iron; acetic acid; sodium nitrite; In ethanol; water;

DOI:10.1002/jhet.5570340541

upstream raw materials:

(1R,2S,3S,5S)-3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester

Downstream raw materials:

(1R,2S,3S,5S)-3-(3-Amino-4-iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester

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