(1R,2S)-2-(tert-butyldimethylsilyloxy)-1-(3-chlorophenyl)-2-phenylethanamine

Base Information

Chemical Name:(1R,2S)-2-(tert-butyldimethylsilyloxy)-1-(3-chlorophenyl)-2-phenylethanamine
CAS No.:1190201-91-2
Molecular Formula:C₂₀H₂₈ClNOSi
Molecular Weight:361.987
Hs Code.:

Synonyms:(1R,2S)-2-(tert-butyldimethylsilyloxy)-1-(3-chlorophenyl)-2-phenylethanamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2S)-2-(tert-butyldimethylsilyloxy)-1-(3-chlorophenyl)-2-phenylethanamine

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Technology Process of (1R,2S)-2-(tert-butyldimethylsilyloxy)-1-(3-chlorophenyl)-2-phenylethanamine

There total 1 articles about (1R,2S)-2-(tert-butyldimethylsilyloxy)-1-(3-chlorophenyl)-2-phenylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 147329-37-1
(S)-(-)-α-<(tert-butyldimethylsilyl)oxy>benzeneacetonitrile

: 36229-42-2
(3-chlorophenyl)magnesium bromide

: 1190201-91-2
(1R,2S)-2-(tert-butyldimethylsilyloxy)-1-(3-chlorophenyl)-2-phenylethanamine

Guidance literature:: (S)-(-)-α-<(tert-butyldimethylsilyl)oxy>benzeneacetonitrile; (3-chlorophenyl)magnesium bromide; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; diethyl ether; at 20 ℃; for 0.5h; optical yield given as %de; diastereoselective reaction;
DOI:10.1021/jo901548t

Reference yield: 99.0%

: 1190201-91-2
(1R,2S)-2-(tert-butyldimethylsilyloxy)-1-(3-chlorophenyl)-2-phenylethanamine

: 1190202-02-8
(1S,2R)-2-azido-1-(tert-butyldimethylsilyloxy)-2-(3-chlorophenyl)-1-phenylethane

Guidance literature:: With triflic azide; copper(II) sulfate; triethylamine; In methanol; dichloromethane; water; at 20 ℃;
DOI:10.1021/jo901548t