trans (3R,5S)-7-[5-(3-dimethylcarbamoylphenylcarbamoyl)-3,4-bis-(4-fluorophenyl)-1-isopropyl-1H-pyrrolyl]-3,5-dihydroxyhept-6-enoic acid methyl ester

Base Information

Chemical Name:trans (3R,5S)-7-[5-(3-dimethylcarbamoylphenylcarbamoyl)-3,4-bis-(4-fluorophenyl)-1-isopropyl-1H-pyrrolyl]-3,5-dihydroxyhept-6-enoic acid methyl ester
CAS No.:855249-74-0
Molecular Formula:C₃₇H₃₉F₂N₃O₆
Molecular Weight:659.73
Hs Code.:

trans (3R,5S)-7-[5-(3-dimethylcarbamoylphenylcarbamoyl)-3,4-bis-(4-fluorophenyl)-1-isopropyl-1H-pyrrolyl]-3,5-dihydroxyhept-6-enoic acid methyl ester

Synonyms:trans (3R,5S)-7-[5-(3-dimethylcarbamoylphenylcarbamoyl)-3,4-bis-(4-fluorophenyl)-1-isopropyl-1H-pyrrolyl]-3,5-dihydroxyhept-6-enoic acid methyl ester

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Chemical Property of trans (3R,5S)-7-[5-(3-dimethylcarbamoylphenylcarbamoyl)-3,4-bis-(4-fluorophenyl)-1-isopropyl-1H-pyrrolyl]-3,5-dihydroxyhept-6-enoic acid methyl ester

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Technology Process of trans (3R,5S)-7-[5-(3-dimethylcarbamoylphenylcarbamoyl)-3,4-bis-(4-fluorophenyl)-1-isopropyl-1H-pyrrolyl]-3,5-dihydroxyhept-6-enoic acid methyl ester

There total 14 articles about trans (3R,5S)-7-[5-(3-dimethylcarbamoylphenylcarbamoyl)-3,4-bis-(4-fluorophenyl)-1-isopropyl-1H-pyrrolyl]-3,5-dihydroxyhept-6-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 950599-55-0
C₃₇H₃₇F₂N₃O₆

: 855249-74-0
trans (3R,5S)-7-[5-(3-dimethylcarbamoylphenylcarbamoyl)-3,4-bis-(4-fluorophenyl)-1-isopropyl-1H-pyrrolyl]-3,5-dihydroxyhept-6-enoic acid methyl ester

Guidance literature:: With sodium tetrahydroborate; diethyl methoxy borane; acetic acid; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1016/j.bmcl.2007.05.096

Reference yield:

: 855248-38-3
3,4-bis-(4-fluoro-phenyl)-5-formyl-1-isopropyl-1H-pyrrole-2-carboxylic acid

: 855249-74-0
trans (3R,5S)-7-[5-(3-dimethylcarbamoylphenylcarbamoyl)-3,4-bis-(4-fluorophenyl)-1-isopropyl-1H-pyrrolyl]-3,5-dihydroxyhept-6-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: SOCl₂ / 80 °C

2: Et₃N / tetrahydrofuran / 12 h / 25 °C

3: toluene / 48 h / 110 °C

4: aq. HF / acetonitrile / 2 h / 0 °C

5: Et₂B(OMe); NaBH₄; AcOH / tetrahydrofuran / 2 h / -78 °C

With sodium tetrahydroborate; thionyl chloride; diethyl methoxy borane; hydrogen fluoride; acetic acid; triethylamine; In tetrahydrofuran; toluene; acetonitrile; 3: Wittig olefination;
DOI:10.1016/j.bmcl.2007.05.096

Reference yield:

: 1027038-69-2
C₂₁H₁₆ClF₂NO₂

: 855249-74-0
trans (3R,5S)-7-[5-(3-dimethylcarbamoylphenylcarbamoyl)-3,4-bis-(4-fluorophenyl)-1-isopropyl-1H-pyrrolyl]-3,5-dihydroxyhept-6-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / tetrahydrofuran / 12 h / 25 °C

2: toluene / 48 h / 110 °C

3: aq. HF / acetonitrile / 2 h / 0 °C

4: Et₂B(OMe); NaBH₄; AcOH / tetrahydrofuran / 2 h / -78 °C

With sodium tetrahydroborate; diethyl methoxy borane; hydrogen fluoride; acetic acid; triethylamine; In tetrahydrofuran; toluene; acetonitrile; 2: Wittig olefination;
DOI:10.1016/j.bmcl.2007.05.096