(3R,5R)-7-[5-(3-dimethylcarbamoylphenylcarbamoyl)-3,4-bis-(4-fluorophenyl)-1-isopropyl-1H-pyrrolyl]-3,5-dihydroxyheptanoic acid methyl ester

Base Information

Chemical Name:(3R,5R)-7-[5-(3-dimethylcarbamoylphenylcarbamoyl)-3,4-bis-(4-fluorophenyl)-1-isopropyl-1H-pyrrolyl]-3,5-dihydroxyheptanoic acid methyl ester
CAS No.:855249-76-2
Molecular Formula:C₃₇H₄₁F₂N₃O₆
Molecular Weight:661.746
Hs Code.:

Synonyms:(3R,5R)-7-[5-(3-dimethylcarbamoylphenylcarbamoyl)-3,4-bis-(4-fluorophenyl)-1-isopropyl-1H-pyrrolyl]-3,5-dihydroxyheptanoic acid methyl ester

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Chemical Property of (3R,5R)-7-[5-(3-dimethylcarbamoylphenylcarbamoyl)-3,4-bis-(4-fluorophenyl)-1-isopropyl-1H-pyrrolyl]-3,5-dihydroxyheptanoic acid methyl ester

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Technology Process of (3R,5R)-7-[5-(3-dimethylcarbamoylphenylcarbamoyl)-3,4-bis-(4-fluorophenyl)-1-isopropyl-1H-pyrrolyl]-3,5-dihydroxyheptanoic acid methyl ester

There total 15 articles about (3R,5R)-7-[5-(3-dimethylcarbamoylphenylcarbamoyl)-3,4-bis-(4-fluorophenyl)-1-isopropyl-1H-pyrrolyl]-3,5-dihydroxyheptanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 855249-74-0
trans (3R,5S)-7-[5-(3-dimethylcarbamoylphenylcarbamoyl)-3,4-bis-(4-fluorophenyl)-1-isopropyl-1H-pyrrolyl]-3,5-dihydroxyhept-6-enoic acid methyl ester

: 855249-76-2
(3R,5R)-7-[5-(3-dimethylcarbamoylphenylcarbamoyl)-3,4-bis-(4-fluorophenyl)-1-isopropyl-1H-pyrrolyl]-3,5-dihydroxyheptanoic acid methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; at 25 ℃; for 3h;
DOI:10.1016/j.bmcl.2007.05.096

Reference yield:

: 855248-38-3
3,4-bis-(4-fluoro-phenyl)-5-formyl-1-isopropyl-1H-pyrrole-2-carboxylic acid

: 855249-76-2
(3R,5R)-7-[5-(3-dimethylcarbamoylphenylcarbamoyl)-3,4-bis-(4-fluorophenyl)-1-isopropyl-1H-pyrrolyl]-3,5-dihydroxyheptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: SOCl₂ / 80 °C

2: Et₃N / tetrahydrofuran / 12 h / 25 °C

3: toluene / 48 h / 110 °C

4: aq. HF / acetonitrile / 2 h / 0 °C

5: Et₂B(OMe); NaBH₄; AcOH / tetrahydrofuran / 2 h / -78 °C

6: H₂ / Pd/C / ethanol; tetrahydrofuran / 3 h / 25 °C

With sodium tetrahydroborate; thionyl chloride; diethyl methoxy borane; hydrogen fluoride; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; toluene; acetonitrile; 3: Wittig olefination;
DOI:10.1016/j.bmcl.2007.05.096

Reference yield:

: 1027038-69-2
C₂₁H₁₆ClF₂NO₂

: 855249-76-2
(3R,5R)-7-[5-(3-dimethylcarbamoylphenylcarbamoyl)-3,4-bis-(4-fluorophenyl)-1-isopropyl-1H-pyrrolyl]-3,5-dihydroxyheptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / tetrahydrofuran / 12 h / 25 °C

2: toluene / 48 h / 110 °C

3: aq. HF / acetonitrile / 2 h / 0 °C

4: Et₂B(OMe); NaBH₄; AcOH / tetrahydrofuran / 2 h / -78 °C

5: H₂ / Pd/C / ethanol; tetrahydrofuran / 3 h / 25 °C

With sodium tetrahydroborate; diethyl methoxy borane; hydrogen fluoride; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; toluene; acetonitrile; 2: Wittig olefination;
DOI:10.1016/j.bmcl.2007.05.096