N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.0^2,7]undec-5-en-5-yl]-1-methyl-1-oxo-1λ⁶-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

Base Information

• Chemical Name: N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.0^2,7]undec-5-en-5-yl]-1-methyl-1-oxo-1λ⁶-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide
• CAS No.: 1086106-29-7
• Molecular Formula: C₂₆H₂₇FN₄O₅S₂
• Molecular Weight: 558.655
• Mol file: 1086106-29-7.mol

Synonyms:N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.0^2,7]undec-5-en-5-yl]-1-methyl-1-oxo-1λ⁶-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

Chemical Property of N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.0^2,7]undec-5-en-5-yl]-1-methyl-1-oxo-1λ⁶-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.0^2,7]undec-5-en-5-yl]-1-methyl-1-oxo-1λ⁶-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide

There total 19 articles about N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.0^2,7]undec-5-en-5-yl]-1-methyl-1-oxo-1λ⁶-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,2S,7R,8S)-5-(-7-amino-1-methyl-1-oxo-1λ6benzo[1,2,4]thiadiazin-3-yl)-3-(4-fluoro-benzyl)-6-hydroxy-3-aza-tricyclo[6.2.1.02,7]undec-5-en-4-one (1086106-51-5) + methanesulfonyl chloride (124-63-0) → N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.02,7]undec-5-en-5-yl]-1-methyl-1-oxo-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide (1086106-29-7)

Guidance literature:

With pyridine; In acetone; at 20 ℃; for 7h;

Reference yield:

(1S,2S,3R,4R)-3-ethoxycarbonyl-bicyclo[2.2.1]hept-2-yl-ammonium (1'S)-(+)-10-camphorsulfonate (1071520-32-5) → N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.02,7]undec-5-en-5-yl]-1-methyl-1-oxo-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide (1086106-29-7)

Guidance literature:

Multi-step reaction with 5 steps

1: water; sodium carbonate / ethyl acetate / 0.5 h / 25 °C

2: sodium cyanoborohydride; acetic acid / ethanol / 3 h / 20 - 25 °C

3: triethylamine / N,N-dimethyl acetamide; toluene / 116 - 150 °C

4: hydrazine / nickel / tetrahydrofuran; methanol; water / 1.83 h / 0 - 20 °C

5: pyridine / acetone / 7 h / 20 °C

With pyridine; water; sodium cyanoborohydride; sodium carbonate; acetic acid; triethylamine; hydrazine; nickel; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl acetamide; water; ethyl acetate; acetone; toluene;

Reference yield:

1,3-dimethyl-7-nitro-1λ4-benzo[1,2,4]thiadiazine 1-oxide (1086106-62-8) → N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.02,7]undec-5-en-5-yl]-1-methyl-1-oxo-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide (1086106-29-7)

Guidance literature:

Multi-step reaction with 6 steps

1: sodium hydroxide; water / 0.33 h / 100 °C

2: diethyl ether; N,N-dimethyl acetamide / 16 h / 20 °C

3: triethylamine / toluene / 20 h / 110 °C

4: triethylamine / N,N-dimethyl acetamide; toluene / 116 - 150 °C

5: hydrazine / nickel / tetrahydrofuran; methanol; water / 1.83 h / 0 - 20 °C

6: pyridine / acetone / 7 h / 20 °C

With pyridine; sodium hydroxide; water; triethylamine; hydrazine; nickel; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl acetamide; water; acetone; toluene;

upstream raw materials:

(1R,2S,7R,8S)-5-(-7-amino-1-methyl-1-oxo-1λ⁶benzo[1,2,4]thiadiazin-3-yl)-3-(4-fluoro-benzyl)-6-hydroxy-3-aza-tricyclo[6.2.1.0^2,7]undec-5-en-4-one

methanesulfonyl chloride

1,3-dimethyl-1λ⁴-benzo[e][1,2,4]thiadiazine 1-oxide

N-(2-methylsulfanyl-phenyl)-acetamide