(1R,2R)-2-(4-bromophenyl)-1-(tert-butoxycarbonylamino)cyclopropanecarboxylic acid

Base Information

Chemical Name:(1R,2R)-2-(4-bromophenyl)-1-(tert-butoxycarbonylamino)cyclopropanecarboxylic acid
CAS No.:1401625-49-7
Molecular Formula:C₁₅H₁₈BrNO₄
Molecular Weight:356.216
Hs Code.:

Synonyms:(1R,2R)-2-(4-bromophenyl)-1-(tert-butoxycarbonylamino)cyclopropanecarboxylic acid

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Chemical Property of (1R,2R)-2-(4-bromophenyl)-1-(tert-butoxycarbonylamino)cyclopropanecarboxylic acid

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Technology Process of (1R,2R)-2-(4-bromophenyl)-1-(tert-butoxycarbonylamino)cyclopropanecarboxylic acid

There total 2 articles about (1R,2R)-2-(4-bromophenyl)-1-(tert-butoxycarbonylamino)cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1161813-60-0
(1R,2R)-methyl 1-amino-2-(4-bromophenyl)cyclopropanecarboxylate

: 1401625-49-7
(1R,2R)-2-(4-bromophenyl)-1-(tert-butoxycarbonylamino)cyclopropanecarboxylic acid

Guidance literature:: (1R,2R)-methyl 1-amino-2-(4-bromophenyl)cyclopropanecarboxylate; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; water; pH=8;

di-tert-butyl dicarbonate;

Reference yield:

: methyl-1-amino-2-(4-bromophenyl)cyclopropane-1-carboxylate

: 1401625-49-7
(1R,2R)-2-(4-bromophenyl)-1-(tert-butoxycarbonylamino)cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: O,O'-dibenzoyl-L-tartaric acid / ethyl acetate; methanol / 2 h

1.2: 0.5 h

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 20 °C

2.2: pH 8

With lithium hydroxide monohydrate; water; O,O'-dibenzoyl-L-tartaric acid; In tetrahydrofuran; methanol; ethyl acetate;

Reference yield: 85.0%

: 1401625-49-7
(1R,2R)-2-(4-bromophenyl)-1-(tert-butoxycarbonylamino)cyclopropanecarboxylic acid

: 1401625-50-0
tert-butyl (1R,2R)-2-(4-bromophenyl)-4-carbamoylcyclopropylcarbamate

Guidance literature:: (1R,2R)-2-(4-bromophenyl)-1-(tert-butoxycarbonylamino)cyclopropanecarboxylic acid; With 4-methyl-morpholine; chloroformic acid ethyl ester; In dichloromethane; at 0 ℃; for 1h;

With ammonia; In dichloromethane; at 20 ℃;