tert-butyl (1R,2R)-2-(4-bromophenyl)-4-carbamoylcyclopropylcarbamate

Base Information

Chemical Name:tert-butyl (1R,2R)-2-(4-bromophenyl)-4-carbamoylcyclopropylcarbamate
CAS No.:1401625-50-0
Molecular Formula:C₁₅H₁₉BrN₂O₃
Molecular Weight:355.231
Hs Code.:

Synonyms:tert-butyl (1R,2R)-2-(4-bromophenyl)-4-carbamoylcyclopropylcarbamate

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Chemical Property of tert-butyl (1R,2R)-2-(4-bromophenyl)-4-carbamoylcyclopropylcarbamate

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Technology Process of tert-butyl (1R,2R)-2-(4-bromophenyl)-4-carbamoylcyclopropylcarbamate

There total 3 articles about tert-butyl (1R,2R)-2-(4-bromophenyl)-4-carbamoylcyclopropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1401625-49-7
(1R,2R)-2-(4-bromophenyl)-1-(tert-butoxycarbonylamino)cyclopropanecarboxylic acid

: 1401625-50-0
tert-butyl (1R,2R)-2-(4-bromophenyl)-4-carbamoylcyclopropylcarbamate

Guidance literature:: (1R,2R)-2-(4-bromophenyl)-1-(tert-butoxycarbonylamino)cyclopropanecarboxylic acid; With 4-methyl-morpholine; chloroformic acid ethyl ester; In dichloromethane; at 0 ℃; for 1h;

With ammonia; In dichloromethane; at 20 ℃;

Reference yield:

: 1161813-60-0
(1R,2R)-methyl 1-amino-2-(4-bromophenyl)cyclopropanecarboxylate

: 1401625-50-0
tert-butyl (1R,2R)-2-(4-bromophenyl)-4-carbamoylcyclopropylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 20 °C

1.2: pH 8

2.1: chloroformic acid ethyl ester; 4-methyl-morpholine / dichloromethane / 1 h / 0 °C

2.2: 20 °C

With 4-methyl-morpholine; lithium hydroxide monohydrate; water; chloroformic acid ethyl ester; In tetrahydrofuran; dichloromethane;

Reference yield:

: methyl-1-amino-2-(4-bromophenyl)cyclopropane-1-carboxylate

: 1401625-50-0
tert-butyl (1R,2R)-2-(4-bromophenyl)-4-carbamoylcyclopropylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: O,O'-dibenzoyl-L-tartaric acid / ethyl acetate; methanol / 2 h

1.2: 0.5 h

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 20 °C

2.2: pH 8

3.1: chloroformic acid ethyl ester; 4-methyl-morpholine / dichloromethane / 1 h / 0 °C

3.2: 20 °C

With 4-methyl-morpholine; lithium hydroxide monohydrate; water; chloroformic acid ethyl ester; O,O'-dibenzoyl-L-tartaric acid; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;