(2S,5S)-2,5-bis[3,5-bis(trifluoromethyl)phenyl]tetrahydrothiophene

Base Information

Chemical Name:(2S,5S)-2,5-bis[3,5-bis(trifluoromethyl)phenyl]tetrahydrothiophene
CAS No.:1451012-50-2
Molecular Formula:C₂₀H₁₂F₁₂S
Molecular Weight:512.362
Hs Code.:

Synonyms:(2S,5S)-2,5-bis[3,5-bis(trifluoromethyl)phenyl]tetrahydrothiophene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,5S)-2,5-bis[3,5-bis(trifluoromethyl)phenyl]tetrahydrothiophene

Chemical Property:

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Technology Process of (2S,5S)-2,5-bis[3,5-bis(trifluoromethyl)phenyl]tetrahydrothiophene

There total 5 articles about (2S,5S)-2,5-bis[3,5-bis(trifluoromethyl)phenyl]tetrahydrothiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1R,4R)-1,4-bis(methanesulfonyloxy)-1,4-bis(3,5-bis-(trifluoromethyl)phenyl)butane

: 1451012-50-2
(2S,5S)-2,5-bis[3,5-bis(trifluoromethyl)phenyl]tetrahydrothiophene

Guidance literature:: With sodiumsulfide nonahydrate; In ethanol; at 25 ℃; for 0.5h; enantioselective reaction; Inert atmosphere;
DOI:10.1055/s-0033-1338865

Reference yield:

: 107337-73-5
(3,5-bis(trifluoromethyl)phenyl)lithium

: 1451012-50-2
(2S,5S)-2,5-bis[3,5-bis(trifluoromethyl)phenyl]tetrahydrothiophene

Guidance literature:: Multi-step reaction with 4 steps

1.1: diethyl ether / -78 °C / Inert atmosphere

1.2: 1 h / 25 °C / Inert atmosphere

2.1: (S)-diphenylprolinol; dimethylsulfide borane complex; Trimethyl borate / toluene; tetrahydrofuran / 0.5 h / 40 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 1 h / -20 - 0 °C / Inert atmosphere

4.1: sodiumsulfide nonahydrate / ethanol / 0.5 h / 25 °C / Inert atmosphere

With sodiumsulfide nonahydrate; Trimethyl borate; (S)-diphenylprolinol; dimethylsulfide borane complex; triethylamine; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; toluene; 1.1: |Weinreb Ketone Synthesis;
DOI:10.1055/s-0033-1338865

Reference yield:

: 1123200-71-4
1,4-bis(3,5-bis(trifluoromethyl)phenyl)butane-1,4-dione

: 1451012-50-2
(2S,5S)-2,5-bis[3,5-bis(trifluoromethyl)phenyl]tetrahydrothiophene

Guidance literature:: Multi-step reaction with 3 steps

1: (S)-diphenylprolinol; dimethylsulfide borane complex; Trimethyl borate / toluene; tetrahydrofuran / 0.5 h / 40 °C / Inert atmosphere

2: triethylamine / dichloromethane / 1 h / -20 - 0 °C / Inert atmosphere

3: sodiumsulfide nonahydrate / ethanol / 0.5 h / 25 °C / Inert atmosphere

With sodiumsulfide nonahydrate; Trimethyl borate; (S)-diphenylprolinol; dimethylsulfide borane complex; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; toluene;
DOI:10.1055/s-0033-1338865