2-methyl-5-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene

Base Information

Chemical Name:2-methyl-5-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene
CAS No.:1263307-42-1
Molecular Formula:C₁₇H₂₁BO₂S
Molecular Weight:300.23
Hs Code.:

Synonyms:2-methyl-5-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene

Suppliers and Price of 2-methyl-5-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-methyl-5-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene

Chemical Property:

Purity/Quality:: 98%+ ^*data from raw suppliers

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Technology Process of 2-methyl-5-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene

There total 6 articles about 2-methyl-5-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 61285-25-4
3-bromo-2-methyl-5-phenylthiophene

: 94584-18-6
2-isopropoxy-4,4,5,5,-tetramethyl-1,3,2-dioxaborane

: 1263307-42-1
2-methyl-5-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene

Guidance literature:: 3-bromo-2-methyl-5-phenylthiophene; With n-butyllithium; In tetrahydrofuran; hexane; for 1h; Inert atmosphere;

2-isopropoxy-4,4,5,5,-tetramethyl-1,3,2-dioxaborane; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jacs.8b02982

Reference yield: 93.0%

: 61285-25-4
3-bromo-2-methyl-5-phenylthiophene

: 61676-62-8
2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1263307-42-1
2-methyl-5-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene

Guidance literature:: 3-bromo-2-methyl-5-phenylthiophene; With n-butyllithium; In diethyl ether; at -78 ℃; for 1h; Inert atmosphere;

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; In diethyl ether; at -78 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1002/asia.201500328

Reference yield:

: 554-14-3
2-Methylthiophene

: 1263307-42-1
2-methyl-5-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene

Guidance literature:: Multi-step reaction with 4 steps

1.1: bromine; acetic acid / 1 h / 0 - 20 °C

1.2: 2 h / 0 - 20 °C

2.1: n-butyllithium / diethyl ether / 1 h / -78 - 70 °C / Inert atmosphere

2.2: -70 - 20 °C / Inert atmosphere

3.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 70 °C / Inert atmosphere

4.1: n-butyllithium / diethyl ether / 1 h / -78 °C / Inert atmosphere

4.2: 1 h / -78 - 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; bromine; sodium carbonate; acetic acid; In tetrahydrofuran; diethyl ether;
DOI:10.1002/asia.201500328