tert-butyl {tert-butoxycarbonyl[6-({4-[butyryl(methyl)amino]benzyl}(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-yl]amino}acetate

Base Information

Chemical Name:tert-butyl {tert-butoxycarbonyl[6-({4-[butyryl(methyl)amino]benzyl}(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-yl]amino}acetate
CAS No.:1273386-39-2
Molecular Formula:C₃₄H₄₅N₅O₇S
Molecular Weight:667.827
Hs Code.:

Synonyms:tert-butyl {tert-butoxycarbonyl[6-({4-[butyryl(methyl)amino]benzyl}(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-yl]amino}acetate

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Chemical Property of tert-butyl {tert-butoxycarbonyl[6-({4-[butyryl(methyl)amino]benzyl}(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-yl]amino}acetate

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Technology Process of tert-butyl {tert-butoxycarbonyl[6-({4-[butyryl(methyl)amino]benzyl}(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-yl]amino}acetate

There total 9 articles about tert-butyl {tert-butoxycarbonyl[6-({4-[butyryl(methyl)amino]benzyl}(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-yl]amino}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: tert-butyl (tert-butoxycarbonyl{6-[(4-methylaminobenzyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl}amino)acetate

: 141-75-3
butyryl chloride

: 1273386-39-2
tert-butyl {tert-butoxycarbonyl[6-({4-[butyryl(methyl)amino]benzyl}(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-yl]amino}acetate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h; Cooling with ice;

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1273386-39-2
tert-butyl {tert-butoxycarbonyl[6-({4-[butyryl(methyl)amino]benzyl}(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-yl]amino}acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.33 h / 20 °C / Inert atmosphere; Cooling with ice

1.2: 1.17 h / 20 °C / Cooling with ice

2.1: calcium chloride / ethanol / 0.33 h / Cooling with ice

2.2: 0.58 h / 20 - 35 °C

3.1: Dess-Martin periodane / dichloromethane / 2.33 h / 20 °C / Cooling with ice; Inert atmosphere

4.1: pyridine; hydroxylamine hydrochloride / methanol; ethyl acetate

5.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 1 h / 20 °C / 760.05 Torr

6.1: triethylamine / dichloromethane / 1 h / 20 °C

7.1: tributylphosphine; diamide / tetrahydrofuran / 8.5 h / 20 °C

8.1: triethylamine / dichloromethane / 3 h / 20 °C / Cooling with ice

With pyridine; tributylphosphine; diamide; hydroxylamine hydrochloride; hydrogen; sodium hydride; Dess-Martin periodane; triethylamine; calcium chloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 203321-86-2
6-tert-butoxycarbonylamino-pyridine-2-carboxylic acid ethyl ester

: 1273386-39-2
tert-butyl {tert-butoxycarbonyl[6-({4-[butyryl(methyl)amino]benzyl}(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-yl]amino}acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.33 h / 20 °C / Inert atmosphere; Cooling with ice

1.2: 1.17 h / 20 °C / Cooling with ice

2.1: calcium chloride / ethanol / 0.33 h / Cooling with ice

2.2: 0.58 h / 20 - 35 °C

3.1: Dess-Martin periodane / dichloromethane / 2.33 h / 20 °C / Cooling with ice; Inert atmosphere

4.1: pyridine; hydroxylamine hydrochloride / methanol; ethyl acetate

5.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 1 h / 20 °C / 760.05 Torr

6.1: triethylamine / dichloromethane / 1 h / 20 °C

7.1: tributylphosphine; diamide / tetrahydrofuran / 8.5 h / 20 °C

8.1: triethylamine / dichloromethane / 3 h / 20 °C / Cooling with ice

With pyridine; tributylphosphine; diamide; hydroxylamine hydrochloride; hydrogen; sodium hydride; Dess-Martin periodane; triethylamine; calcium chloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;