[6-({4-[butyryl(methyl)amino]benzyl}(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino]acetic acid

Base Information

Chemical Name:[6-({4-[butyryl(methyl)amino]benzyl}(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino]acetic acid
CAS No.:1273386-25-6
Molecular Formula:C₂₅H₂₉N₅O₅S
Molecular Weight:511.602
Hs Code.:

Synonyms:[6-({4-[butyryl(methyl)amino]benzyl}(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino]acetic acid

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Chemical Property of [6-({4-[butyryl(methyl)amino]benzyl}(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino]acetic acid

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Technology Process of [6-({4-[butyryl(methyl)amino]benzyl}(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino]acetic acid

There total 9 articles about [6-({4-[butyryl(methyl)amino]benzyl}(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1273386-39-2
tert-butyl {tert-butoxycarbonyl[6-({4-[butyryl(methyl)amino]benzyl}(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-yl]amino}acetate

: 1273386-25-6
[6-({4-[butyryl(methyl)amino]benzyl}(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino]acetic acid

Guidance literature:: tert-butyl {tert-butoxycarbonyl[6-({4-[butyryl(methyl)amino]benzyl}(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-yl]amino}acetate; With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 7h;

With sodium hydroxide; In water; pH=4.7;

Reference yield:

: 203321-86-2
6-tert-butoxycarbonylamino-pyridine-2-carboxylic acid ethyl ester

: 1273386-25-6
[6-({4-[butyryl(methyl)amino]benzyl}(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino]acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.33 h / 20 °C / Inert atmosphere; Cooling with ice

1.2: 1.17 h / 20 °C / Cooling with ice

2.1: calcium chloride / ethanol / 0.33 h / Cooling with ice

2.2: 0.58 h / 20 - 35 °C

3.1: Dess-Martin periodane / dichloromethane / 2.33 h / 20 °C / Cooling with ice; Inert atmosphere

4.1: pyridine; hydroxylamine hydrochloride / methanol; ethyl acetate

5.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 1 h / 20 °C / 760.05 Torr

6.1: triethylamine / dichloromethane / 1 h / 20 °C

7.1: tributylphosphine; diamide / tetrahydrofuran / 8.5 h / 20 °C

8.1: triethylamine / dichloromethane / 3 h / 20 °C / Cooling with ice

9.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 7 h / 20 °C

9.2: pH 4.7

With pyridine; hydrogenchloride; tributylphosphine; diamide; hydroxylamine hydrochloride; hydrogen; sodium hydride; Dess-Martin periodane; triethylamine; calcium chloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1187450-49-2
tert-butyl (tert-butoxycarbonyl(6-(hydroxymethyl)pyridin-2-yl)amino)acetate

: 1273386-25-6
[6-({4-[butyryl(methyl)amino]benzyl}(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino]acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: Dess-Martin periodane / dichloromethane / 2.33 h / 20 °C / Cooling with ice; Inert atmosphere

2.1: pyridine; hydroxylamine hydrochloride / methanol; ethyl acetate

3.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 1 h / 20 °C / 760.05 Torr

4.1: triethylamine / dichloromethane / 1 h / 20 °C

5.1: tributylphosphine; diamide / tetrahydrofuran / 8.5 h / 20 °C

6.1: triethylamine / dichloromethane / 3 h / 20 °C / Cooling with ice

7.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 7 h / 20 °C

7.2: pH 4.7

With pyridine; hydrogenchloride; tributylphosphine; diamide; hydroxylamine hydrochloride; hydrogen; Dess-Martin periodane; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate;