(2S,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-fluoro-4-hydroxy-pentanoic acid methyl ester

Base Information

Chemical Name:(2S,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-fluoro-4-hydroxy-pentanoic acid methyl ester
CAS No.:1028289-72-6
Molecular Formula:C₂₂H₂₉FO₄Si
Molecular Weight:404.554
Hs Code.:

Synonyms:(2S,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-fluoro-4-hydroxy-pentanoic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-fluoro-4-hydroxy-pentanoic acid methyl ester

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Technology Process of (2S,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-fluoro-4-hydroxy-pentanoic acid methyl ester

There total 2 articles about (2S,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-fluoro-4-hydroxy-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-(tert-butyl-diphenyl-silanyloxymethyl)-3-fluoro-5H-furan-2-one

: 1028289-72-6
(2S,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-fluoro-4-hydroxy-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 94 percent / H₂ / 5 percent Pd/C / ethyl acetate / 3 h

2.1: NaOH / ethanol; H₂O / 2 h / 20 °C

2.2: dimethylsulfoxide / 1 h

With sodium hydroxide; hydrogen; 5 percent Pd/C; In ethanol; water; ethyl acetate;
DOI:10.1021/jm020246+

Reference yield:

: 77-78-1
dimethyl sulfate

: 476209-84-4
(2S,4S)-(+)-4-tert-butyldiphenylsilyloxymethyl-2-fluoro-γ-butyrolactone

: 1028289-72-6
(2S,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-2-fluoro-4-hydroxy-pentanoic acid methyl ester

Guidance literature:: (2S,4S)-(+)-4-tert-butyldiphenylsilyloxymethyl-2-fluoro-γ-butyrolactone; With sodium hydroxide; In ethanol; water; at 20 ℃; for 2h;

dimethyl sulfate; In dimethyl sulfoxide; for 1h; Further stages.;
DOI:10.1021/jm020246+